Non-bone-derived exosomes: a new perspective on regulators of bone homeostasis

被引：7

作者：

Wang, Ping ^{[1
]}

Shao, Wenkai ^{[1
]}

Li, Zilin ^{[1
]}

Wang, Bo ^{[2
]}

Lv, Xiao ^{[1
]}

Huang, Yiyao ^{[3
]}

Feng, Yong ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Orthoped, Wuhan 430022, Peoples R China

[2] Huazhong Univ Sci & Technol, Wuhan No Hosp 1, Tongji Med Coll, Dept Rehabil, Wuhan 430030, Peoples R China

[3] Southern Med Univ, Nanfang Hosp, Dept Lab Med, Guangzhou 510515, Guangdong, Peoples R China

来源：

CELL COMMUNICATION AND SIGNALING | 2024年 / 22卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Exosomes; Non-bone-derived exosomes; Bone-related diseases; Bone homeostasis; Extracellular vesicles; TRAUMATIC BRAIN-INJURY; ADIPOSE STEM-CELLS; EXTRACELLULAR VESICLES; ESCRT MACHINERY; FEMORAL-HEAD; OSTEOBLASTIC DIFFERENTIATION; OSTEOGENIC DIFFERENTIATION; INDUCED OSTEONECROSIS; BIOGENESIS; CANCER;

D O I：

10.1186/s12964-023-01431-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Accumulating evidence indicates that exosomes help to regulate bone homeostasis. The roles of bone-derived exosomes have been well-described; however, recent studies have shown that some non-bone-derived exosomes have better bone targeting ability than bone-derived exosomes and that their performance as a drug delivery vehicle for regulating bone homeostasis may be better than that of bone-derived exosomes, and the sources of non-bone-derived exosomes are more extensive and can thus be better for clinical needs. Here, we sort non-bone-derived exosomes and describe their composition and biogenesis. Their roles and specific mechanisms in bone homeostasis and bone-related diseases are also discussed. Furthermore, we reveal obstacles to current research and future challenges in the practical application of exosomes, and we provide potential strategies for more effective application of exosomes for the regulation of bone homeostasis and the treatment of bone-related diseases.67yBviMJcTRjcZnyRK6kR4Video Abstract

引用

页数：23

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