Rare loss-of-function variants reveal threshold and multifactorial inheritance of dextrocardia

被引：9

作者：

Chen, Zhongzhong ^{[1
]}

Gao, Yunqian ^{[1
,2
]}

Lu, Lei ^{[3
]}

Li, Nan ^{[4
]}

Liu, Pei ^{[3
]}

Peng, Rui ^{[1
]}

Liu, Lingling ^{[1
]}

Huang, Hefeng ^{[5
]}

Fu, Qihua ^{[2
]}

Hong, Haifa ^{[6
]}

Zhang, Jianguo ^{[4
]}

Wang, Hongyan ^{[1
,3
,7
]}

机构：

[1] Fudan Univ, Obstet & Gynecol Hosp, Inst Reprod & Dev, State Key Lab Genet Engn, Shanghai 200011, Peoples R China

[2] Shanghai Jiao Tong Univ, Pediat Translat Med Inst, Shanghai Childrens Med Ctr, Sch Med, Shanghai 200127, Peoples R China

[3] Fudan Univ, Inst Metab & Integrat Biol, Shanghai Key Lab Metab Remodeling & Hlth, Shanghai 200438, Peoples R China

[4] BGI Genom, Shenzhen 518083, Peoples R China

[5] Fudan Univ, Obstet & Gynecol Hosp, Shanghai 200090, Peoples R China

[6] Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Dept Cardiothorac Surg, Sch Med, Shanghai 200127, Peoples R China

[7] Fudan Univ, Childrens Hosp, Shanghai 201102, Peoples R China

来源：

SCIENCE BULLETIN | 2023年 / 68卷 / 18期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

CONGENITAL HEART-DISEASE; GENETICS; GENES; CILIA;

D O I：

10.1016/j.scib.2023.08.005

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

[No abstract available]

引用

页码：1993 / 1998

页数：6

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