Effect of Cannabinoids on Brain Metabolites: A Review of Animal and Human Studies

被引:2
|
作者
Ma, Jiyoung [1 ,2 ]
Lyoo, In Kyoon [1 ,2 ,3 ]
Renshaw, Perry F. [1 ,2 ,4 ]
Yurgelun-Todd, Deborah A. [1 ,2 ,4 ]
机构
[1] Univ Utah, Sch Med, Dept Psychiat, 383 Colorow Dr, Salt Lake City, UT 84108 USA
[2] Univ Utah, Diagnost Neuroimaging Lab, Salt Lake City, UT 84108 USA
[3] Ewha W Univ, Ewha Brain Inst, Seoul, South Korea
[4] Vet Affairs VISN 19 Rocky Mt, Mental Illness Res Educ & Clin Ctr MIRECC, Salt Lake City, UT USA
基金
新加坡国家研究基金会;
关键词
cannabis; delta-9-tetrahydrocannabinol; cannabidiol; magnetic resonance spectroscopy; MAGNETIC-RESONANCE-SPECTROSCOPY; GLOBAL HYPOXIA-ISCHEMIA; ENDOCANNABINOID SYSTEM; PREFRONTAL CORTEX; CANNABIDIOL; GLUTAMATE; MARIJUANA; MECHANISMS; GABA; MODEL;
D O I
10.1037/pha0000553
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Cannabis has been widely used medically and recreationally for centuries. With a renewed interest in the therapeutic use of cannabinoids, which are active components of Cannabis sativa, it has become important to understand the cannabinoids' neurobiological mechanisms related to both therapeutic and harmful effects. This review summarizes the effects of two major cannabinoids, delta-9-tetrahydrocannabinol and cannabidiol, on brain metabolites. We focus on human studies applying H-1-magnetic resonance spectroscopy (MRS) and animal studies using more invasive and direct methods to measure brain metabolites associated with glutamatergic neurotransmission or glial and neuronal functions. Although studies are limited in number, current evidence suggests that two major cannabinoids, which are thought to have differential effects on the brain, may alter the brain metabolite levels in distinct ways from each other. Potential limitations of present studies of cannabinoids on brain metabolites and suggestions regarding future studies are also discussed. We believe that issues clarified in this review may contribute to the design of future studies of cannabinoids on brain metabolites. Public Health Significance Understanding how cannabinoids act in the brain is important for the development of cannabis-derived therapies. This review summarizes the studies demonstrating the effects of two major cannabinoids, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), on brain metabolites. Distinct effects of THC and CBD on brain metabolite levels and suggestions for future studies are discussed in this review.
引用
收藏
页码:248 / 262
页数:15
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