Synthesis and application of bacterial exopolysaccharides

被引：14

作者：

Ruijgrok, Gijs ^{[1
]}

Wu, Dung-Yeh ^{[1
]}

Overkleeft, Herman S. ^{[1
]}

Codee, Jeroen D. C. ^{[1
]}

机构：

[1] Leiden Univ, Leiden Inst Chem, Einsteinweg 55, NL-2333 CC Leiden, Netherlands

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2024年 / 78卷

关键词：

Glycosylation; Biofilm; Stereoselectivity; Polysaccharide; PSEUDOMONAS-AERUGINOSA; O-ACETYLATION; POLYSACCHARIDE; ALGINATE; ANTIBODIES; ACID; PSL; MECHANISM; OLIGOSACCHARIDES; IDENTIFICATION;

D O I：

10.1016/j.cbpa.2023.102418

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Exopolysaccharides are produced and excreted by bacteria in the generation of biofilms to provide a protective environment. These polysaccharides are generally generated as heteroge-neous polymers of varying length, featuring diverse substitu-tion patterns. To obtain well-defined fragments of these polysaccharides, organic synthesis often is the method of choice, as it allows for full control over chain length and the installation of a pre-determined substitution pattern. This review presents several recent syntheses of exopoly-saccharide fragments of Pseudomonas aeruginosa and Staphylococcus aureus and illustrates how these have been used to study biosynthesis enzymes and generate synthetic glycoconjugate vaccines.

引用

页数：8

共 63 条

[11] Mechanism of a Chemical Glycosylation Reaction [J].

Crich, David .

ACCOUNTS OF CHEMICAL RESEARCH, 2010, 43 (08) :1144-1153

[12] Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens [J].

Cywes-Bentley, Colette ;

Skurnik, David ;

Zaidi, Tanweer ;

Roux, Damien ;

DeOliveira, Rosane B. ;

Garrett, Wendy S. ;

Lu, Xi ;

O'Malley, Jennifer ;

Kinzel, Kathryn ;

Zaidi, Tauqeer ;

Rey, Astrid ;

Perrin, Christophe ;

Fichorova, Raina N. ;

Kayatani, Alexander K. K. ;

Maira-Litran, Tomas ;

Gening, Marina L. ;

Tsvetkov, Yury E. ;

Nifantiev, Nikolay E. ;

Bakaletz, Lauren O. ;

Pelton, Stephen I. ;

Golenbock, Douglas T. ;

Pier, Gerald B. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (24) :E2209-E2218

[13] Identification of broadly protective human antibodies to Pseudomonas aeruginosa exopolysaccharide Psl by phenotypic screening [J].

DiGiandomenico, Antonio ;

Warrener, Paul ;

Hamilton, Melissa ;

Guillard, Sandrine ;

Ravn, Peter ;

Minter, Ralph ;

Camara, Maria Margarita ;

Venkatraman, Vignesh ;

MacGill, Randall S. ;

Lin, Jia ;

Wang, Qun ;

Keller, Ashley Elaine ;

Bonnell, Jessica C. ;

Tomich, Mladen ;

Jermutus, Lutz ;

McCarthy, Michael P. ;

Melnick, David A. ;

Suzich, JoAnn A. ;

Stover, C. Kendall .

JOURNAL OF EXPERIMENTAL MEDICINE, 2012, 209 (07) :1273-1287

[14] Biosynthesis of the Pseudomonas aeruginosa extracellular polysaccharides, alginate, Pel, and Psl [J].

Franklin, Michael J. ;

Nivens, David E. ;

Weadge, Joel T. ;

Howell, P. Lynne .

FRONTIERS IN MICROBIOLOGY, 2011, 2

[15]

Gening Marina L, 2020, Drug Discov Today Technol, V35-36, P13, DOI 10.1016/j.ddtec.2020.09.002

[16] Synthetic β-(1→6)-Linked N-Acetylated and Nonacetylated Oligoglucosamines Used To Produce Conjugate Vaccines for Bacterial Pathogens [J].

Gening, Marina L. ;

Maira-Litran, Tomas ;

Kropec, Andrea ;

Skurnik, David ;

Grout, Martha ;

Tsvetkov, Yury E. ;

Nifantiev, Nikolay E. ;

Pier, Gerald B. .

INFECTION AND IMMUNITY, 2010, 78 (02) :764-772

[17] Chronic biofilm-based infections: skewing of the immune response [J].

Gonzalez, Juan F. ;

Hahn, Mark M. ;

Gunn, John S. .

PATHOGENS AND DISEASE, 2018, 76 (03)

[18] Di-tert-butylsilylene (DTBS) group-directed α-selective galactosylation unaffected by C-2 participating functionalities [J].

Imamura, A ;

Ando, H ;

Korogi, S ;

Tanabe, G ;

Muraoka, O ;

Ishida, H ;

Kiso, M .

TETRAHEDRON LETTERS, 2003, 44 (35) :6725-6728

[19] Self-produced exopolysaccharide is a signal that stimulates biofilm formation in Pseudomonas aeruginosa [J].

Irie, Yasuhiko ;

Borlee, Bradley R. ;

O'Connor, Jennifer R. ;

Hill, Preston J. ;

Harwood, Caroline S. ;

Wozniak, Daniel J. ;

Parsek, Matthew R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (50) :20632-20636

[20] Pseudomonas aeruginosa aggregates in cystic fibrosis sputum produce exopolysaccharides that likely impede current therapies [J].

Jennings, Laura K. ;

Dreifus, Julia E. ;

Reichhardt, Courtney ;

Storek, Kelly M. ;

Secor, Patrick R. ;

Wozniak, Daniel J. ;

Hisert, Katherine B. ;

Parsek, Matthew R. .

CELL REPORTS, 2021, 34 (08)

← 1 2 3 4 5 6 7 →