Synthesis and application of bacterial exopolysaccharides

被引：14

作者：

Ruijgrok, Gijs ^{[1
]}

Wu, Dung-Yeh ^{[1
]}

Overkleeft, Herman S. ^{[1
]}

Codee, Jeroen D. C. ^{[1
]}

机构：

[1] Leiden Univ, Leiden Inst Chem, Einsteinweg 55, NL-2333 CC Leiden, Netherlands

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2024年 / 78卷

关键词：

Glycosylation; Biofilm; Stereoselectivity; Polysaccharide; PSEUDOMONAS-AERUGINOSA; O-ACETYLATION; POLYSACCHARIDE; ALGINATE; ANTIBODIES; ACID; PSL; MECHANISM; OLIGOSACCHARIDES; IDENTIFICATION;

D O I：

10.1016/j.cbpa.2023.102418

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Exopolysaccharides are produced and excreted by bacteria in the generation of biofilms to provide a protective environment. These polysaccharides are generally generated as heteroge-neous polymers of varying length, featuring diverse substitu-tion patterns. To obtain well-defined fragments of these polysaccharides, organic synthesis often is the method of choice, as it allows for full control over chain length and the installation of a pre-determined substitution pattern. This review presents several recent syntheses of exopoly-saccharide fragments of Pseudomonas aeruginosa and Staphylococcus aureus and illustrates how these have been used to study biosynthesis enzymes and generate synthetic glycoconjugate vaccines.

引用

页数：8

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