The function and regulation of CCAAT/enhancer binding protein ε

被引：1

作者：

Cheng, Shaowen

Yang, Jian

Wang, Yudie

Xian, Lina

Hu, Zhihua

Zou, Lingyun

机构：

[1] Department of Emergency and Traumatology, First Affiliated Hospital of Hainan Medical University, Haikou

[2] Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Medical University, Haikou

[3] Research Unit of Island Emergency Medicine, Chinese Academy of Medical Sciences (No. 2019RU013), Hainan Medical University, Haikou

[4] Emergency and Trauma College, Hainan Medical University, Haikou

[5] Intensive Care Unit, Hainan Medical University, Haikou

[6] Center for Clinical Data Research, Chongqing University Central Hospital, Chongqing

来源：

EUROPEAN JOURNAL OF INFLAMMATION | 2023年 / 21卷

基金：

海南省自然科学基金; 中国国家自然科学基金;

关键词：

C; EBP & epsilon; structure; function; regulation; ACUTE MYELOID-LEUKEMIA; C/EBP-EPSILON; GENE; TRANSCRIPTION; EXPRESSION; ACETYLATION; DOMAIN; CELLS; METHYLATION; MATURATION;

D O I：

10.1177/1721727X231153322

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In recent years, studies on the structure, function, and regulation of the C/EBP & epsilon; gene have become an essential topic in the field of many diseases. CCAAT/enhancer-binding protein & epsilon; (C/EBP & epsilon;) is the fifth member of the transcription factor CCAAT/C/EBP family of transcription factors. It plays crucial roles in cell proliferation, differentiation, immunity, energy metabolism, and hematopoiesis. C/EBP & epsilon; plays essential roles in regulating the hematopoietic system, including myeloid cell development and maturation, participation in the body 's immune responses, and prevention of infections. C/EBP & epsilon; function is regulated by phosphorylation, acetylation, methylation, and other types of genes. This review related to C/EBP & epsilon; structure, function and regulation provides a theoretical basis for subsequent research in this area. C/EBP & epsilon; is an emerging therapeutic target and thus provides new strategies for disease prevention and control.

引用

页数：8

共 42 条

[1]

ALLEN JD, 1993, BLOOD, V81, P3242

[2] DEFECTIVE BACTERICIDAL ACTIVITY AND ABSENCE OF SPECIFIC GRANULES IN NEUTROPHILS FROM A PATIENT WITH RECURRENT BACTERIAL-INFECTIONS [J].

AMBRUSO, DR ;

SASADA, M ;

NISHIYAMA, H ;

KUBO, A ;

KOMIYAMA, A ;

ALLEN, RH .

JOURNAL OF CLINICAL IMMUNOLOGY, 1984, 4 (01) :23-30

[3] A novel human CCAAT/enhancer binding protein gene, C/EBP epsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus [J].

Antonson, P ;

Stellan, B ;

Yamanaka, R ;

Xanthopoulos, KG .

GENOMICS, 1996, 35 (01) :30-38

[4] Acetylation of C/EBPε is a prerequisite for terminal neutrophil differentiation [J].

Bartels, Marije ;

Govers, Anita M. ;

Fleskens, Veerle ;

Lourenco, Ana Rita ;

Pals, Cornelieke E. ;

Vervoort, Stephin J. ;

van Gent, Rogier ;

Brenkman, Arjan B. ;

Bierings, Marc B. ;

Ackerman, Steven J. ;

van Loosdregt, Jorg ;

Coffer, Paul J. .

BLOOD, 2015, 125 (11) :1782-1792

[5] Human C/EBP-ε activator and repressor isoforms differentially reprogram myeloid lineage commitment and differentiation [J].

Bedi, Richa ;

Du, Jian ;

Sharma, Arun K. ;

Gomes, Ignatius ;

Ackerman, Steven J. .

BLOOD, 2009, 113 (02) :317-327

[6] Protein partners of C/EBPε [J].

Chih, DY ;

Park, DJ ;

Gross, M ;

Idos, G ;

Vuong, PT ;

Hirama, T ;

Chumakov, AA ;

Said, J ;

Koeffler, HP .

EXPERIMENTAL HEMATOLOGY, 2004, 32 (12) :1173-1181

[7] Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor [J].

Chumakov, AM ;

Grillier, I ;

Chumakova, E ;

Chih, D ;

Slater, J ;

Koeffler, HP .

MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (03) :1375-1386

[8] BIPOTENTIAL PRECURSORS OF B-CELLS AND MACROPHAGES IN MURINE FETAL LIVER [J].

CUMANO, A ;

PAIGE, CJ ;

ISCOVE, NN ;

BRADY, G .

NATURE, 1992, 356 (6370) :612-615

[9] The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia [J].

Gale, Rosemary E. ;

Green, Claire ;

Allen, Christopher ;

Mead, Adam J. ;

Burnett, Alan K. ;

Hils, Robert K. ;

Linch, David C. .

BLOOD, 2008, 111 (05) :2776-2784

[10] Acetylation and deacetylation of non-histone proteins [J].

Glozak, MA ;

Sengupta, N ;

Zhang, XH ;

Seto, E .

GENE, 2005, 363 :15-23

← 1 2 3 4 5 →