Interplay of the microbiome and antifungal therapy in recurrent vulvovaginal candidiasis (RVVC): A narrative review

被引:4
作者
Strydom, Moira Bradfield [1 ]
Khan, Sohil [1 ,2 ]
Walpola, Ramesh L. [3 ]
Ware, Robert S. [2 ]
Tiralongo, Evelin [1 ]
机构
[1] Griffith Univ, Sch Pharm & Med Sci, Gold Coast, Qld, Australia
[2] Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast, Qld, Australia
[3] UNSW Sydney, Fac Med & Hlth, Sch Hlth Sci, Sydney, NSW, Australia
关键词
microbiome; candidiasis; RVVC; recurrent thrush; fluconazole; FLUCONAZOLE THERAPY; FUNGAL FLORA; WOMEN; COLONIZATION; LACTOBACILLUS; FRIEND;
D O I
10.1099/jmm.0.001705
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Recurrent vulvovaginal candidiasis (RVVC) is a microbial, immune and sexual health disorder impacting up to 10 % of the adult female population. Fluconazole is a well- established antifungal drug commonly utilized for acute and long- term RVVC treatment. This insight review provides an overview of known vaginal and gastrointestinal microbiota characteristics in RVVC, presents the potential impacts of fluconazole therapy on multi- microbiome relationships and discusses implications for future research and clinical practice. Next- generation sequencing (NGS) and molecular methods to accurately define vaginal microbiota trends in RVVC are not comprehensively available, limiting understanding of microbiota roles in RVVC. Inconsistencies and variances in Lactobacillus profiles in RVVC women suggest poorly understood disease implications on the bacterial and fungal microbiomes. Investigations of environmental conditions like vaginal pH, drug therapy's impact, especially fluconazole maintenance therapy, and the elucidation of multi- microbiome relationships in RVVC are required to further investigate disease pathogenesis and responsible antimicrobial prescribing.
引用
收藏
页数:7
相关论文
共 51 条
[1]   THE EFFECT OF TREATMENT REGIMENS FOR VAGINITIS AND CERVICITIS ON VAGINAL COLONIZATION BY LACTOBACILLI [J].
AGNEW, KJ ;
HILLIER, SL .
SEXUALLY TRANSMITTED DISEASES, 1995, 22 (05) :269-273
[2]   Highlights Regarding Host Predisposing Factors to Recurrent Vulvovaginal Candidiasis: Chronic Stress and Reduced Antioxidant Capacity [J].
Akimoto-Gunther, Luciene ;
Bonfim-Mendonca, Patricia de Souza ;
Takahachi, Gisele ;
Irie, Mary Mayumi T. ;
Miyamoto, Sonia ;
Lopes Consolaro, Marcia Edilaine ;
Estivalet Svidzinsk, Terezinha I. .
PLOS ONE, 2016, 11 (07)
[3]   Identification of Candida species in vaginal flora using conventional and molecular methods [J].
Ameen, F. ;
Moslem, M. ;
Al Tami, M. ;
Al-Ajlan, H. ;
Al-Qahtani, N. .
JOURNAL DE MYCOLOGIE MEDICALE, 2017, 27 (03) :364-368
[4]   Supragingival mycobiome and inter-kingdom interactions in dental caries [J].
Baraniya, Divyashri ;
Chen, Tsute ;
Nahar, Anubhav ;
Alakwaa, Fadhl ;
Hill, Jennifer ;
Tellez, Marisol ;
Ismail, Amid ;
Puri, Sumant ;
Al-Hebshi, Nezar Noor .
JOURNAL OF ORAL MICROBIOLOGY, 2020, 12 (01)
[5]   Vaginal yeast colonization in nonpregnant women: A longitudinal study [J].
Beigi, RH ;
Meyn, LA ;
Moore, DM ;
Krohn, MA ;
Hillier, SL .
OBSTETRICS AND GYNECOLOGY, 2004, 104 (05) :926-930
[6]   Chronic vulvovaginal Candida hypersensitivity: An underrecognized and undertreated disorder by allergists [J].
Bernstein, Jonathan A. ;
Seidu, Luqman .
ALLERGY & RHINOLOGY, 2015, 6 (01) :E44-E49
[7]   The vaginal mycobiome: A contemporary perspective on fungi in women's health and diseases [J].
Bradford, L. Latey ;
Ravel, Jacques .
VIRULENCE, 2017, 8 (03) :342-351
[8]   The Vaginal Microbiota and Behavioral Factors Associated With Genital Candida albicans Detection in Reproductive-Age Women [J].
Brown, Sarah E. ;
Schwartz, Jennifer A. ;
Robinson, Courtney K. ;
O'Hanlon, D. Elizabeth ;
Bradford, L. Latey ;
He, Xin ;
Mark, Katrina S. ;
Bruno, Vincent M. ;
Ravel, Jacques ;
Brotman, Rebecca M. .
SEXUALLY TRANSMITTED DISEASES, 2019, 46 (11) :753-758
[9]   Diversity of vaginal microbiome and metabolome during genital infections [J].
Ceccarani, Camilla ;
Foschi, Claudio ;
Parolin, Carola ;
D'Antuono, Antonietta ;
Gaspari, Valeria ;
Consolandi, Clarissa ;
Laghi, Luca ;
Camboni, Tania ;
Vitali, Beatrice ;
Severgnini, Marco ;
Marangoni, Antonella .
SCIENTIFIC REPORTS, 2019, 9 (1)
[10]   Prognosis and Long-Term Outcome of Women With Idiopathic Recurrent Vulvovaginal Candidiasis Caused by Candida albicans [J].
Collins, Laura M. ;
Moore, Rachelle ;
Sobel, Jack D. .
JOURNAL OF LOWER GENITAL TRACT DISEASE, 2020, 24 (01) :48-52