Notch Signaling in Acute Inflammation and Sepsis

被引：33

作者：

Gallenstein, Nadia ^{[1
]}

Tichy, Lucas ^{[1
]}

Weigand, Markus Alexander ^{[1
]}

Schenz, Judith ^{[1
]}

机构：

[1] Heidelberg Univ Hosp, Dept Anesthesiol, D-69120 Heidelberg, Germany

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 04期

关键词：

Jagged; DLL; SIRS; infection; immune cells; immune response; Notch; therapy; inflammation; sepsis; NF-KAPPA-B; ENDOTHELIAL GROWTH-FACTOR; SECRETASE INHIBITOR DAPT; HEMATOPOIETIC STEM-CELLS; NEGATIVE BREAST-CANCER; DELTA-LIKE; T-CELLS; PROMOTES DIFFERENTIATION; ATTENUATES INFLAMMATION; LYMPHOCYTE DEVELOPMENT;

D O I：

10.3390/ijms24043458

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Notch signaling, a highly conserved pathway in mammals, is crucial for differentiation and homeostasis of immune cells. Besides, this pathway is also directly involved in the transmission of immune signals. Notch signaling per se does not have a clear pro- or anti-inflammatory effect, but rather its impact is highly dependent on the immune cell type and the cellular environment, modulating several inflammatory conditions including sepsis, and therefore significantly impacts the course of disease. In this review, we will discuss the contribution of Notch signaling on the clinical picture of systemic inflammatory diseases, especially sepsis. Specifically, we will review its role during immune cell development and its contribution to the modulation of organ-specific immune responses. Finally, we will evaluate to what extent manipulation of the Notch signaling pathway could be a future therapeutic strategy.

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页数：26

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