Morphologic and genomic changes of thyroid cancer cell lines exposed to conditions of simulated microgravity

被引:6
作者
Ahn, Jong-hyuk [1 ,2 ]
Park, Sungyeon [3 ]
Hwang, Young Mi [4 ]
Choi, Yun Suk [1 ,5 ]
Yi, Jin Wook [1 ,5 ]
机构
[1] lnha Univ, Dept Surg, Coll Med, Incheon, South Korea
[2] Chungbuk Natl Univ Hosp, Dept Surg, Cheongju, South Korea
[3] Inha Univ Korea, Coll Med, Dept Pathol, Incheon, South Korea
[4] Inha Univ Res, Business Fdn, Res Inst Med Sci, Incheon, South Korea
[5] lnha Univ Hosp, Dept Surg, Dept Neurol, Incheon, South Korea
基金
新加坡国家研究基金会;
关键词
GENE-EXPRESSION; ESTABLISHMENT; PATHWAYS; PROTEINS;
D O I
10.1038/s41526-024-00346-y
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Microgravity in space impacts human health. In particular, thyroid cancer, which has a high incidence rate, has been the subject of numerous studies with respect to microgravity. However, most studies have focused on Western follicular thyroid cancer cell lines, while data regarding the effects of microgravity on Asian cell lines are lacking. Therefore, we aimed to investigate the effect of simulated ground-based microgravity on two Korean thyroid cancer cell lines, namely SNU-790 and SNU-80. We found that both cell lines formed multicellular spheroids under simulated microgravity. Gene expression analysis revealed that in SNU-790 cells, histone-related genes were upregulated and microRNA-related genes were downregulated. Meanwhile, in SNU-80 cells, genes related to the cellular response to hypoxia were downregulated. These findings contribute to a better understanding of the effects of microgravity on thyroid cancer cells. Further validation studies and clinical significance analyses are needed to fully understand the implications of these findings.
引用
收藏
页数:14
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