Association of Fine Particulate Matter Constituents with the Predicted 10-Year Atherosclerotic Cardiovascular Disease Risk: Evidence from a Large-Scale Cross-Sectional Study

被引:2
作者
Wang, Sheng [1 ]
Zhao, Ge [1 ]
Zhang, Caiyun [2 ]
Kang, Ning [2 ]
Liao, Wei [2 ]
Wang, Chongjian [2 ]
Xie, Fuwei [1 ]
机构
[1] Zhengzhou Tobacco Res Inst CNTC, Key Lab Tobacco Chem, Zhengzhou 450003, Peoples R China
[2] Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol & Biostat, Zhengzhou 450001, Peoples R China
关键词
PM2.5; constituents; BC; ASCVD; rural area; LONG-TERM EXPOSURE; AMBIENT AIR-POLLUTION; SOCIOECONOMIC-STATUS; CHEMICAL-COMPOSITION; PM2.5; CONSTITUENTS; PHYSICAL-ACTIVITY; BLACK CARBON; MORTALITY; POPULATION; CHINA;
D O I
10.3390/toxics11100812
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Little is known concerning the associations of fine particulate matter (PM2.5) and its constituents with atherosclerotic cardiovascular disease (ASCVD). A total of 31,162 participants enrolled from the Henan Rural Cohort were used to specify associations of PM2.5 and its constituents with ASCVD. Hybrid machine learning was utilized to estimate the 3-year average concentration of PM2.5 and its constituents (black carbon [BC], nitrate [NO3-], ammonium [NH4+], inorganic sulfate [SO42-], organic matter [OM], and soil particles [SOIL]). Constituent concentration, proportion, and residual models were utilized to examine the associations of PM2.5 constituents with 10-year ASCVD risk and to identify the most hazardous constituent. The isochronous substitution model (ISM) was employed to analyze the substitution effect between PM2.5 constituents. We found that each 1 mu g/m(3) increase in PM2.5, BC, NH4+, NO3-, OM, SO42-, and SOIL was associated with a 3.5%, 49.3%, 19.4%, 10.5%, 21.4%, 14%, and 28.5% higher 10-year ASCVD risk, respectively (all p < 0.05). Comparable results were observed in proportion and residual models. The ISM found that replacing BC with other constituents will generate the greatest health benefits. The results indicated that long-term exposure to PM2.5 and its constituents were associated with increased risks of ASCVD, with BC being the most attributable constituent.
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页数:14
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