Exploiting Chirality in Confined Nanospaces

Spatial organization using confinement has been of great interest since the early ages of supramolecular chemistry. Application such as sensing, catalysis and delivery are continuously emerging. This minireview highlights the evolution of chiral supramolecular cages (CSC) applications in the fields of catalysis, sensing and chiroptical properties. More in detail, beside the description of the strategies adopted for the preparation of chiral supramolecular cages, either of purely organic supramolecular architectures or prepared using metal-ligand coordination bonds, recent findings on their applications, with particular attention to stereodynamic systems, are presented to highlight the recent scientific interests and the future opportunities. The development of novel synthetic strategies for the preparation of chiral supramolecular cages has led in the recent years to a boost on their applications. This minireview highlights some recent examples on the applications that these systems have found in catalysis, sensing and in the development of systems with novel chiral optical activities.image