Spatial analyses of immune cell infiltration in cancer: current methods and future directions. A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer

被引：19

作者：

Page, David B. ^{[1
]}

Broeckx, Glenn ^{[2
,3
]}

Jahangir, Chowdhury Arif

Jahangir, Chowdhury ^{[4
]}

Verbandt, Sara ^{[5
]}

Gupta, Rajarsi R. ^{[6
]}

Thagaard, Jeppe ^{[7
,8
]}

Khiroya, Reena ^{[9
]}

Kos, Zuzana ^{[10
]}

Abduljabbar, Khalid ^{[11
]}

Acosta Haab, Gabriela ^{[12
]}

Acs, Balazs ^{[13
,14
]}

Almeida, Jonas S. ^{[15
]}

Alvarado-Cabrero, Isabel ^{[16
]}

Azmoudeh-Ardalan, Farid ^{[17
]}

Badve, Sunil ^{[18
]}

Baharun, Nurkhairul Bariyah ^{[19
]}

Bellolio, Enrique R. ^{[20
]}

Bheemaraju, Vydehi ^{[21
]}

Blenman, Kim R. M. ^{[22
,23
,24
]}

Botinelly Mendonca Fujimoto, Luciana ^{[25
]}

Burgues, Octavio ^{[26
]}

Cheang, Maggie Chon U. ^{[27
]}

Ciompi, Francesco ^{[28
]}

Cooper, Lee A. D. ^{[29
]}

Coosemans, An ^{[30
]}

Corredor, German ^{[31
]}

Dantas Portela, Flavio Luis ^{[32
]}

Deman, Frederik ^{[2
]}

Demaria, Sandra ^{[33
,34
]}

Dudgeon, Sarah N. ^{[35
]}

Elghazawy, Mahmoud ^{[36
,37
]}

Ely, Scott ^{[38
]}

Fernandez-Martin, Claudio ^{[39
]}

Fineberg, Susan ^{[40
,41
]}

Fox, Stephen B. ^{[4
,42
,43
]}

Gallagher, William M. ^{[4
]}

Giltnane, Jennifer M. ^{[44
]}

Gnjatic, Sacha ^{[45
]}

Gonzalez-Ericsson, Paula, I ^{[46
]}

Grigoriadis, Anita ^{[47
,48
]}

Halama, Niels ^{[49
]}

Hanna, Matthew G. ^{[50
]}

Harbhajanka, Aparna ^{[51
]}

Hardas, Alexandros ^{[52
]}

Hart, Steven N. ^{[53
]}

Hartman, Johan ^{[14
,54
]}

Hewitt, Stephen ^{[55
]}

Hida, Akira, I ^{[56
]}

Horlings, Hugo M. ^{[57
]}

机构：

[1] Earle A Chiles Res Inst, Providence Canc Inst, Portland, OR 97213 USA

[2] GZA ZNA Hosp, Dept Pathol, Antwerp, Belgium

[3] Antwerp Univ, Ctr Oncol Res CORE, MIPPRO, Fac Med, Antwerp, Belgium

[4] Univ Coll Dublin, UCD Sch Biomol & Biomed Sci, Dublin, Ireland

[5] Katholieke Univ Leuven, Digest Oncol, Dept Oncol, Leuven, Belgium

[6] SUNY Stony Brook, Dept Biomed Informat, Stony Brook, NY USA

[7] Tech Univ Denmark, Lyngby, Denmark

[8] Visiopharm AS, Horsholm, Denmark

[9] Univ Coll Hosp, Dept Cellular Pathol, London, England

[10] Univ British Columbia, BC Canc Vancouver Ctr, Dept Pathol & Lab Med, Vancouver, BC, Canada

[11] Inst Canc Res, Ctr Evolut & Canc, London, England

[12] Hosp Maria Curie, Buenos Aires, DF, Argentina

[13] Karolinska Inst, Dept Pathol & Oncol, Stockholm, Sweden

[14] Karolinska Univ Hosp, Clin Pathol & Canc Diagnost, Stockholm, Sweden

[15] Natl Canc Inst, Div Canc Epidemiol & Genet DCEG, Rockville, MD USA

[16] Star Medica Ctr, Oncol Hosp, Mexico City, DF, Mexico

[17] Univ Tehran Med Sci, Tehran, Iran

[18] Emory Univ, Winship Canc Inst, Pathol & Lab Med, Sch Med, Atlanta, GA USA

[19] Natl Univ Malaysia, Kuala Lumpur, Malaysia

[20] Univ La Frontera, Fac Med, Dept Anat Patol, Temuco, Chile

[21] Narayana Med Coll, Dept Pathol, Nellore, India

[22] Yale Sch Med, Internal Med Sect Med Oncol, New Haven, CT USA

[23] Yale Sch Med, Yale Canc Ctr, New Haven, CT USA

[24] Yale Sch Engn & Appl Sci, Comp Sci, New Haven, CT USA

[25] Amazonas Fed Univ, Manaus, Amazonas, Brazil

[26] Hosp Clin Univ Valencia Incliva, Pathol Dept, Valencia, Spain

[27] ICR CTSU, Inst Canc Res, Div Clin Studies, Head Integrat Genom Anal Clin Trials, London, England

[28] Radboud Univ Nijmegen, Dept Pathol, Med Ctr, Nijmegen, Netherlands

[29] Northwestern Feinberg Sch Med, Dept Pathol, Chicago, IL USA

[30] Katholieke Univ Leuven, Dept Oncol, Lab Tumor Immunol & Immunotherapy, Leuven, Belgium

[31] Emory Univ, Biomed Engn Dept, Atlanta, GA USA

[32] Hosp Univ Getulio Vargas, Manaus, Amazonas, Brazil

[33] Weill Cornell Med Coll, Dept Radiat Oncol, New York, NY USA

[34] Weill Cornell Med, Dept Pathol, New York, NY USA

[35] Yale Univ, Conputat Biol & Bioinformat, New Haven, CT USA

[36] Univ Surrey, Guildford, Surrey, England

[37] Ain Shams Univ, Cairo, Egypt

[38] Bristol Myers Squibb, Translat Pathol Translat Sci & Diagnost Translat, Bristol, NJ USA

[39] Univ Politecn Valencia, Inst Univ Investigaci Tecnol Centrada El Ser Huma, HUMAN Tech, Valencia, Spain

[40] Montefiore Med Ctr, New York, NY USA

[41] Albert Einstein Coll Med, New York, NY USA

[42] Univ Melbourne, Dept Pathol, Peter MacCallum Canc Ctr, Melbourne, Vic, Australia

[43] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia

[44] Genentech Inc, San Francisco, CA USA

[45] Icahn Sch Med Mt Sinai, Dept Oncol Sci Med HemOnc & Pathol, Tisch Canc Inst, Precis Immunol Inst, New York, NY USA

[46] Vanderbilt Univ, Dept Med, Med Ctr, Nashville, TN USA

[47] Kings Coll London, Sch Canc & Pharmaceut Sci, Fac Life Sci & Med, Canc Bioinformat, London, England

[48] Kings Coll London, Sch Canc & Pharmaceut Sci, Fac Life Sci & Med, Breast Canc Now Res Unit, London, England

[49] German Canc Res Ctr, Translat Immunotherapy, Heidelberg, Germany

[50] Mem Sloan Kettering Canc Ctr, New York, NY USA

来源：

JOURNAL OF PATHOLOGY | 2023年 / 260卷 / 05期

基金：

澳大利亚国家健康与医学研究理事会; 日本学术振兴会; 英国工程与自然科学研究理事会; 英国医学研究理事会; 爱尔兰科学基金会; 美国国家卫生研究院; 欧盟地平线“2020”;

关键词：

spatial statistics; tumor infiltrating lymphocytes; TIL; sTIL score; Immunoscore; multispectral immunofluorescence; spatial heterogeneity; DENSITY; LYMPHOCYTES; METASTASES; THERAPY;

D O I：

10.1002/path.6165

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Modern histologic imaging platforms coupled with machine learning methods have provided new opportunities to map the spatial distribution of immune cells in the tumor microenvironment. However, there exists no standardized method for describing or analyzing spatial immune cell data, and most reported spatial analyses are rudimentary. In this review, we provide an overview of two approaches for reporting and analyzing spatial data (raster versus vector-based). We then provide a compendium of spatial immune cell metrics that have been reported in the literature, summarizing prognostic associations in the context of a variety of cancers. We conclude by discussing two well-described clinical biomarkers, the breast cancer stromal tumor infiltrating lymphocytes score and the colon cancer Immunoscore, and describe investigative opportunities to improve clinical utility of these spatial biomarkers. & COPY; 2023 The Pathological Society of Great Britain and Ireland.

引用

页码：514 / 532

页数：19

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