The role of regulated necrosis in inflammation and ocular surface diseases

被引：4
作者：
Guo, Xiao-Xiao [1 ]
Pu, Qi [1 ]
Hu, Jing-Jie [1 ]
Chang, Xue-Jiao [1 ]
Li, Ao-Ling [1 ]
Li, Xin-Yu [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Ophthalmol, Wuhan 430030, Hubei, Peoples R China
来源：
EXPERIMENTAL EYE RESEARCH | 2023年 / 233卷
关键词：
Pyroptosis; Ferroptosis; Necroptosis; Inflammation; Ocular surface diseases; GLUTATHIONE-PEROXIDASE; 4; MIXED LINEAGE KINASE; GROUP BOX 1; CELL-DEATH; PROGRAMMED NECROSIS; MOLECULAR-MECHANISMS; NLRP3; INFLAMMASOME; NONCODING RNA; GASDERMIN D; DRY EYE;
D O I：
10.1016/j.exer.2023.109537
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
In recent decades, numerous types of regulated cell death have been identified, including pyroptosis, ferroptosis and necroptosis. Regulated necrosis is characterized by a series of amplified inflammatory responses that result in cell death. Therefore, it has been suggested to play an essential role in the pathogenesis of ocular surface diseases. The cell morphological features and molecular mechanisms of regulated necrosis are discussed in this review. Furthermore, it summarizes the role of ocular surface diseases, such as dry eye, keratitis, and cornea alkali burn, as potential disease prevention and treatment targets.
引用
收藏
页数：11
相关论文
共 142 条
  • [1] Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions
    Aglietti, Robin A.
    Dueber, Erin C.
    [J]. TRENDS IN IMMUNOLOGY, 2017, 38 (04) : 261 - 271
  • [2] Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke
    Alim, Ishraq
    Caulfield, Joseph T.
    Chen, Yingxin
    Swarup, Vivek
    Geschwind, Daniel H.
    Ivanova, Elena
    Seravalli, Javier
    Ai, Youxi
    Sensing, Lauren H.
    Ste Marie, Emma J.
    Hondal, Robert J.
    Mukherjee, Sushmita
    Cave, John W.
    Sagdullaev, Botir T.
    Karuppagounder, Saravanan S.
    Ratan, Rajiv R.
    [J]. CELL, 2019, 177 (05) : 1262 - +
  • [3] Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion
    Angeli, Jose Pedro Friedmann
    Krysko, Dmitri, V
    Conrad, Marcus
    [J]. NATURE REVIEWS CANCER, 2019, 19 (07) : 405 - 414
  • [4] Intraocular expression and release of high-mobility group box 1 protein in retinal detachment
    Arimura, Noboru
    Ki-i, Yuya
    Hashiguchi, Teruto
    Kawahara, Ko-ichi
    Biswas, Kamal K.
    Nakamura, Makoto
    Sonoda, Yasushi
    Yamakiri, Keita
    Okubo, Akiko
    Sakamoto, Taiji
    Maruyama, Ikuro
    [J]. LABORATORY INVESTIGATION, 2009, 89 (03) : 278 - 289
  • [5] Pyroptosis: host cell death and inflammation
    Bergsbaken, Tessa
    Fink, Susan L.
    Cookson, Brad T.
    [J]. NATURE REVIEWS MICROBIOLOGY, 2009, 7 (02) : 99 - 109
  • [6] Inhibition of NLRP3 Inflammasome Pathway by Butyrate Improves Corneal Wound Healing in Corneal Alkali Burn
    Bian, Fang
    Xiao, Yangyan
    Zaheer, Mahira
    Volpe, Eugene A.
    Pflugfelder, Stephen C.
    Li, De-Quan
    de Paiva, Cintia S.
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (03):
  • [7] The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation
    Bonnet, Marion C.
    Preukschat, Daniela
    Welz, Patrick-Simon
    van Loo, Geert
    Ermolaeva, Maria A.
    Bloch, Wilhelm
    Haase, Ingo
    Pasparakis, Manolis
    [J]. IMMUNITY, 2011, 35 (04) : 572 - 582
  • [8] Salmonella induces macrophage death by caspase-1-dependent necrosis
    Brennan, MA
    Cookson, BT
    [J]. MOLECULAR MICROBIOLOGY, 2000, 38 (01) : 31 - 40
  • [9] IMMUNOLOGY Caspase target drives pyroptosis
    Broz, Petr
    [J]. NATURE, 2015, 526 (7575) : 642 - 643
  • [10] Glutathione peroxidase 4: a new player in neurodegeneration?
    Cardoso, B. R.
    Hare, D. J.
    Bush, A. I.
    Roberts, B. R.
    [J]. MOLECULAR PSYCHIATRY, 2017, 22 (03) : 328 - 335
12345678910