Endometriosis affects the number of retrieved oocytes but not early embryonic development and live birth: a retrospective analysis of 716 IVF cycles

被引:0
作者
Bartolacci, Alessandro [1 ]
dell'Aquila, Miriam [1 ]
Coticchio, Giovanni [2 ]
Intra, Giulia [1 ]
Parodi, Federica [1 ]
Patria, Gilda [1 ]
Zaca, Carlotta [2 ]
Borini, Andrea [2 ]
机构
[1] GeneraLife IVF, 9baby, Bergamo, Italy
[2] GeneraLife IVF, 9baby, Bologna, Italy
关键词
Endometriosis; standard in vitro fertilization; blastulation rate; embryo development; live birth; IN-VITRO FERTILIZATION; ASSISTED REPRODUCTION; CONVENTIONAL IVF; WOMEN; IMPACT; INFERTILITY; DYSFUNCTION; ICSI;
D O I
10.1080/14647273.2023.2200979
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
To investigate the potential effect of endometriosis on embryo development and clinical outcomes, a retrospective analysis of 716 women undergoing their first standard in vitrofertilization (sIVF) cycles (205 endometriosis and 511 with tubal factor infertility) was performed. The endometriosis group included women with an ultrasonographic or surgical diagnosis. Control subjects were women diagnosed with tubal factor infertility by laparoscopy or hysterosalpingogram. The primary outcome of the study was live birth. Cumulative live birth was also assessed in a subgroups analysis. After adjusting for confounders we found no significant difference in fertilization rate, blastulation, top-quality blastocyst, live birth, cumulative live birth (subgroups analysis) and miscarriage rate. In the endometriosis group, the number of retrieved oocytes was smaller (6.94 +/- 4.06 Vs 7.50 +/- 4.6, adjusted p < 0.05). We observed a statistically significant difference in the percentage of day-3 embryos with >= 8 blastomeres (33.12 +/- 22.72 endometriosis vs, 40.77 +/- 27.62 tubal factor, adjusted p < 0.01) and a negative correlation between the presence of endometriomas and a number of retrieved oocytes [B coefficient =-1.41, 95%CI (-2.31-0.51), adjusted p = 0.002]. Our results suggest that endometriosis affects the number of retrieved oocytes but not embryo development and live birth.
引用
收藏
页码:1469 / 1476
页数:8
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