m6A Modification-Association with Oxidative Stress and Implications on Eye Diseases

被引：17

作者：

Ni, Yueqi ^{[1
]}

Zhang, Hong ^{[1
]}

Chu, Liang ^{[2
]}

Zhao, Yin ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Ophthalmol, Wuhan 430030, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Hepat Surg Ctr, Wuhan 430030, Peoples R China

来源：

ANTIOXIDANTS | 2023年 / 12卷 / 02期

基金：

中国国家自然科学基金;

关键词：

oxidative stress; m6A modification; eye diseases; treatment; TRABECULAR MESHWORK; MESSENGER-RNA; EPITHELIAL-CELLS; FREE-RADICALS; EMERGING ROLE; DAMAGE; METHYLATION; RETINOPATHY; PROTEIN; M(6)A;

D O I：

10.3390/antiox12020510

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxidative stress (OS) refers to a state of imbalance between oxidation and antioxidation. OS is considered to be an important factor leading to aging and a range of diseases. The eyes are highly oxygen-consuming organs. Due to its continuous exposure to ultraviolet light, the eye is particularly vulnerable to the impact of OS, leading to eye diseases such as corneal disease, cataracts, glaucoma, etc. The N6-methyladenosine (m6A) modification is the most investigated RNA post-transcriptional modification and participates in a variety of cellular biological processes. In this study, we review the role of m6A modification in oxidative stress-induced eye diseases and some therapeutic methods to provide a relatively overall understanding of m6A modification in oxidative stress-related eye diseases.

引用

页数：18

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