Roles and therapeutic potential of different extracellular vesicle subtypes on traumatic brain injury

被引：5
|
作者：
Dong, Xinlong [1 ,2 ]
Dong, Jing-fei [3 ,4 ]
Zhang, Jianning [5 ]
机构：
[1] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, 119 Nansihuan West Rd, Beijing, Peoples R China
[2] Capital Med Univ, Beijing Neurosurg Inst, Beijing Key Lab Cent Nervous Syst Injury, Beijing, Peoples R China
[3] Bloodworks Res Inst, Seattle, WA USA
[4] Univ Washington, Sch Med, Dept Med, Div Hematol, Seattle, WA USA
[5] Tianjin Med Univ, Dept Neurosurg, Gen Hosp, Tianjin, Peoples R China
来源：
CELL COMMUNICATION AND SIGNALING | 2023年 / 21卷 / 01期
关键词：
Traumatic brain injury; Extracellular vesicles; Pathological extracellular vesicles; Biological extracellular vesicles; Engineered special purpose extracellular vesicles; MESENCHYMAL STROMAL CELLS; PROMOTE FUNCTIONAL RECOVERY; DRUG-DELIVERY VEHICLES; HEAD-INJURY; NEURODEGENERATIVE DISEASE; NEUROVASCULAR PLASTICITY; CEREBROSPINAL-FLUID; ALZHEIMERS-DISEASE; NEURITE OUTGROWTH; IMPROVES OUTCOMES;
D O I：
10.1186/s12964-023-01165-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Traumatic brain injury (TBI) is a leading cause of injury-related disability and death around the world, but the clinical stratification, diagnosis, and treatment of complex TBI are limited. Due to their unique properties, extracellular vesicles (EVs) are emerging candidates for being biomarkers of traumatic brain injury as well as serving as potential therapeutic targets. However, the effects of different extracellular vesicle subtypes on the pathophysiology of traumatic brain injury are very different, or potentially even opposite. Before extracellular vesicles can be used as targets for TBI therapy, it is necessary to classify different extracellular vesicle subtypes according to their functions to clarify different strategies for EV-based TBI therapy. The purpose of this review is to discuss contradictory effects of different EV subtypes on TBI, and to propose treatment ideas based on different EV subtypes to maximize their benefits for the recovery of TBI patients.
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页数：30
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