Role and mechanism of DNA methylation and its inhibitors in hepatic fibrosis

被引：15

作者：

Lyu, Shi-Yi ^{[1
]}

Xiao, Wang ^{[2
]}

Cui, Guang-Zu ^{[3
]}

Yu, Cheng ^{[1
]}

Liu, Huan ^{[1
]}

Lyu, Min ^{[1
]}

Kuang, Qian-Ya ^{[1
]}

Xiao, En-Hua ^{[1
]}

Luo, Yong-Heng ^{[1
]}

机构：

[1] Cent South Univ, Xiangya Hosp 2, Dept Radiol, Changsha, Hunan, Peoples R China

[2] Cent South Univ, Xiangya Hosp 2, Dept Gastrointestinal Surg, Changsha, Hunan, Peoples R China

[3] Cent South Univ, XiangYa Sch Med, Changsha, Hunan, Peoples R China

来源：

FRONTIERS IN GENETICS | 2023年 / 14卷

关键词：

hepatic fibrosis; DNA methylation; epigenetics; hepatic stellate cells (HSCs); DNA methylation inhibitors; LIVER FIBROSIS; STELLATE CELLS; MYOFIBROBLAST TRANSDIFFERENTIATION; TUMOR-SUPPRESSOR; MECP2; CONTROLS; CANCER-CELLS; MDX MICE; ACTIVATION; EXPRESSION; ZEBULARINE;

D O I：

10.3389/fgene.2023.1124330

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Liver fibrosis is a repair response to injury caused by various chronic stimuli that continually act on the liver. Among them, the activation of hepatic stellate cells (HSCs) and their transformation into a myofibroblast phenotype is a key event leading to liver fibrosis, however the mechanism has not yet been elucidated. The molecular basis of HSC activation involves changes in the regulation of gene expression without changes in the genome sequence, namely, via epigenetic regulation. DNA methylation is a key focus of epigenetic research, as it affects the expression of fibrosis-related, metabolism-related, and tumor suppressor genes. Increasing studies have shown that DNA methylation is closely related to several physiological and pathological processes including HSC activation and liver fibrosis. This review aimed to discuss the mechanism of DNA methylation in the pathogenesis of liver fibrosis, explore DNA methylation inhibitors as potential therapies for liver fibrosis, and provide new insights on the prevention and clinical treatment of liver fibrosis.

引用

页数：11

共 116 条

[11]

Chen J. Q., 2021, J HIGH ENERGY ASTROP, V31, P2887

[12] Emerging strategies to target RAS signaling in human cancer therapy [J].

Chen, Kun ;

Zhang, Yalei ;

Qian, Ling ;

Wang, Peng .

JOURNAL OF HEMATOLOGY & ONCOLOGY, 2021, 14 (01)

[13] Suppression of SUN2 by DNA methylation is associated with HSCs activation and hepatic fibrosis [J].

Chen, Xin ;

Li, Wan-Xia ;

Chen, Yu ;

Li, Xiao-Feng ;

Li, Hai-Di ;

Huang, Hui-Min ;

Bu, Fang-Tian ;

Pan, Xue-Yin ;

Yang, Yang ;

Huang, Cheng ;

Meng, Xiao-Ming ;

Li, Jun .

CELL DEATH & DISEASE, 2018, 9

[14] Curcumin, both histone deacetylase and p300/CBP-Specific inhibitor, represses the activity of nuclear factor kappa B and Notch 1 in Raji cells [J].

Chen, Yan ;

Shu, Wenxiu ;

Chen, Weihua ;

Wu, Qing ;

Liu, Hongli ;

Cui, Guohui .

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2007, 101 (06) :427-433

[15] Hedgehog Controls Hepatic Stellate Cell Fate by Regulating Metabolism [J].

Chen, Yuping ;

Choi, Steve S. ;

Michelotti, Gregory A. ;

Chan, Isaac S. ;

Swiderska-Syn, Marzena ;

Karaca, Gamze F. ;

Xie, Guanhua ;

Moylan, Cynthia A. ;

Garibaldi, Francesca ;

Premont, Richard ;

Suliman, Hagir B. ;

Piantadosi, Claude A. ;

Diehl, Anna Mae .

GASTROENTEROLOGY, 2012, 143 (05) :1319-+

[16] Role of Mammalian DNA Methyltransferases in Development [J].

Chen, Zhiyuan ;

Zhang, Yi .

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 89, 2020, 89 :135-158

[17] Hepatic macrophages: Key players in the development and progression of liver fibrosis [J].

Cheng, Da ;

Chai, Jin ;

Wang, Huiwen ;

Fu, Lei ;

Peng, Shifang ;

Ni, Xin .

LIVER INTERNATIONAL, 2021, 41 (10) :2279-2294

[18] 生物信息学分析SPP1基因在肝细胞癌中的表达及机制 [J].

成镀 ;

谢鹏 ;

操寄望 .

武汉大学学报(医学版), 2019, 40 (06) :886-890

[19] Inhibition of DNA methylation and reactivation of silenced genes by zebularine [J].

Cheng, JC ;

Matsen, CB ;

Gonzales, FA ;

Ye, W ;

Greer, S ;

Marquez, VE ;

Jones, PA ;

Selker, EU .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2003, 95 (05) :399-409

[20] Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials [J].

Cheng, Yuan ;

He, Cai ;

Wang, Manni ;

Ma, Xuelei ;

Mo, Fei ;

Yang, Shengyong ;

Han, Junhong ;

Wei, Xiawei .

SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2019, 4 (1)

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