Radiographically confirmed community-acquired pneumonia in hospitalized adults due to pneumococcal vaccine serotypes in Sweden, 2016-2018-The ECAPS study

被引：9

作者：

Hansen, Karin ^{[1
,2
]}

Runow, Elisabeth ^{[1
,2
]}

Torisson, Gustav ^{[1
]}

Theilacker, Christian ^{[3
]}

Palmborg, Andreas ^{[4
]}

Pan, Kaijie ^{[3
]}

Jiang, Qin ^{[3
]}

Southern, Jo ^{[3
]}

Beavon, Rohini ^{[3
]}

Gessner, Bradford D. ^{[3
]}

Riesbeck, Kristian ^{[2
]}

Ahl, Jonas ^{[1
,2
]}

机构：

[1] Lund Univ, Fac Med, Dept Translat Med, Sect Infect Dis, Malmo, Sweden

[2] Lund Univ, Fac Med, Dept Translat Med, Sect Clin Microbiol, Malmo, Sweden

[3] Pfizer, Vaccines Global Med Dev Sci & Clin Affairs, Collegeville, PA USA

[4] Pfizer, Vaccines Med Dev Sci & Clin Affairs, Stockholm, Sweden

来源：

FRONTIERS IN PUBLIC HEALTH | 2023年 / 11卷

基金：

瑞典研究理事会;

关键词：

community-acquired pneumonia (CAP); pneumococcal conjugate vaccine; pneumococcal vaccination; Streptococcus pneumoniae; Sweden; CONJUGATE VACCINE; DISEASE; IMMUNOGENICITY; 13-VALENT; CHILDREN; OUTCOMES; IMPACT; SAFETY; TRIAL;

D O I：

10.3389/fpubh.2023.1086648

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

ObjectivesIn Sweden, pneumococcal serotype distribution in adults with community-acquired pneumonia (CAP) and potential coverage of currently licensed pneumococcal conjugate vaccines (PCVs) is unknown. MethodsDuring 2016-2018, patients aged >= 18 years hospitalized with radiologically confirmed (RAD+) CAP were enrolled at Skane University Hospital in a study on the etiology of CAP in Sweden (ECAPS). Urine samples and blood cultures were collected per-protocol. Streptococcus pneumoniae (Spn) culture isolates were serotyped and urine samples tested for the pan-pneumococcal urinary antigen (PUAT) and multiplex urine antigen detection (UAD) assay, detecting 24 serotypes. ResultsAnalyses included 518 participants with RAD+CAP; 67.4% were >= 65 years of age, 73.4% were either immunocompromised or had an underlying chronic medical condition. The proportion of CAP due to Spn identified by any method was 24.3% of which 9.3% was detected by UAD alone. The most frequently identified serotypes were 3 (26 cases, 5.0% of all CAP), and 8, 11A and 19A (10 cases each, 1.9%). In individuals aged 18-64 and >= 65 years, respectively, PCV20 serotypes contributed to 35 of 169 (20.7%) and 53 of 349 cases of all CAP (15.2%), and PCV13 serotypes caused 21 of 169 (12.4%) and 35 of 349 (10.0%) cases. PCV15 coverage was 23 of 169 (13.6%) and 42 of 349 (12.0%) in individuals aged 18-64 and >= 65 years, respectively. Overall, PCV20 increases the coverage of all CAP from 10.8% (PCV13) to 17.0%. ConclusionCompared to earlier pneumococcal vaccines, PCV20 expands the coverage of all-cause CAP. Routine diagnostic tests underestimate the proportion of CAP caused by Spn.

引用

页数：10

共 35 条

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