Synthesis and Antiviral Activity of Copolymers of Hydroxycinnamic Acid with N-Vinylamides

被引：2
作者：
Nesterova, N. A. [1 ]
Shtro, A. A. [2 ]
Panarin, E. F. [1 ]
机构：
[1] Russian Acad Sci, Inst Macromol Cpds, St Petersburg 199004, Russia
[2] Russian Minist Hlth, Smorodintsev Res Inst Influenza, St Petersburg 197376, Russia
来源：
DOKLADY CHEMISTRY | 2023年 / 513卷 / 02期
关键词：
coumarin; copolymers of hydroxycinnamic acid; N-vinylamides; antiviral activity; hydroxycinnamic acid hydrazides;
D O I：
10.1134/S0012500823600992
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Radical copolymerization of coumarin with N-vinylamides (N-vinylpyrrolidone, N-methyl-N-vinylacetamide, N-vinylformamide) has been used to prepare copolymers of various composition with variable molecular weights. Subsequent reactions in their polymer chains affords water-soluble copolymers of salts of hydroxycinnamic acid and its hydrazides. The synthesized copolymers of hydroxycinnamic acid salts and hydrazides with N-vinylamides have low cytotoxicity and demonstrate the pronounced antiviral activity against human respiratory syncytial virus (strain A2).
引用
收藏
页码：389 / 392
页数：4
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