Associations Between Change in Kidney Functioning, Age, Race/Ethnicity, and Health Indicators in the Health and Retirement Study

被引:4
作者
Zhao, Erfei [1 ]
Ailshire, Jennifer [1 ]
Kim, Jung Ki [1 ]
Wu, Qiao [1 ]
Crimmins, Eileen M. [1 ]
机构
[1] Univ Southern Calif, Leonard Davis Sch Gerontol, Los Angeles, CA 90007 USA
来源
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2023年 / 78卷 / 11期
关键词
Aging; Cystatin C; Metabolism; SERUM CYSTATIN-C; AGING KIDNEY; FUNCTION DECLINE; RACIAL DISPARITIES; OLDER-ADULTS; RISK-FACTORS; DISEASE; HYPERTENSION; PROGRESSION; CREATININE;
D O I
10.1093/gerona/glad204
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background: The aging process is accompanied by decline in kidney functioning. It remains unknown to what extent age-related decline in kidney functioning can be attributed to health indicators, and whether rate of decline differs across sociodemographic groups. Methods: Using data from the Health and Retirement Study from 2006/2008 through 2014/2016, we estimated kidney functioning trajectories, determined by cystatin C, among adults aged over 51 over 8 years. We evaluated the role of age, health conditions/behaviors, and genetics in the decline and also examined sociodemographic differentials. Results: Kidney function declined with age and accelerated at older ages, even after adjusting for health conditions/behaviors and genetic differences (eg, 0.019 mg/L annual increase in cystatin C among 70-79 compared to 0.007 mg/L among 52-59 at baseline). Decline occurred faster among those with uncontrolled diabetes (0.008, p =.009), heart conditions (0.007, p <.000), and obesity (0.005, p =.033).Hispanic participants (0.007, p =.039) declined faster than non-Hispanic White persons due to diabetes, heart conditions, and obesity; non-Hispanic Black participants had worse baseline kidney functioning (0.099, p <.000), but only one fourth of this Black-White difference was explained by investigated risk factors. People with higher education experienced slower decline (-0.009, p =.004). Conclusions: Age was a significant predictor of decline in kidney functioning, and its association was not fully explained by health conditions/ behaviors, or genetics. Better management of diabetes, heart conditions, and obesity is effective in slowing this decline. Baseline differences in kidney functioning (eg, between non-Hispanic White and Black persons; those with and without hypertension) suggest disparities occur early in the life course and require early interventions.
引用
收藏
页码:2094 / 2104
页数:11
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