Alternating venetoclax/azacytidine and FLT3 inhibitor treatment for NPM1- and FLT3-mutated acute myeloid leukemia

被引：2
|
作者：
Oya, Shuki [1 ]
Ozawa, Hidetoshi [1 ]
Maehiro, Yoshimi [1 ]
Nakamura, Takayuki [1 ]
Takaki, Yusuke [1 ]
Fukuyama, Toshinobu [1 ]
Yamasaki, Yoshitaka [1 ]
Yamaguchi, Maki [1 ]
Aoyama, Kazutoshi [1 ]
Mouri, Fumihiko [1 ]
Nagafuji, Koji [1 ]
机构：
[1] Kurume Univ, Dept Med, Div Hematol & Oncol, Sch Med, 67 Asahi Machi, Kurume 8300011, Japan
来源：
LEUKEMIA RESEARCH | 2023年 / 130卷
关键词：
Acute myeloid leukemia; Venetoclax; Azacytidine; FLT3; inhibitor; Nucleophosmin; Measurable residual disease; RESIDUAL DISEASE; NUCLEOPHOSMIN; CHEMOTHERAPY; VENETOCLAX;
D O I：
10.1016/j.leukres.2023.107313
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页数：4
相关论文
共 50 条
  • [41] GNF-7, a novel FLT3 inhibitor, overcomes drug resistance for the treatment of FLT3‑ITD acute myeloid leukemia
    Xinhua Xiao
    Peihong Wang
    Weina Zhang
    Jiayi Wang
    Mansi Cai
    Hua Jiang
    Yingli Wu
    Huizhuang Shan
    Cancer Cell International, 23
  • [42] Efficacy and Safety of Clifutinib, a Novel, Highly Selective, Oral FLT3 Inhibitor, in Patients with FLT3-Mutated Relapsed or Refractory Acute Myeloid Leukemia:Updated Results from a Phase I Study
    Jin, Jie
    Wang, Huafeng
    Yu, Wen-Juan
    Ge, Zheng
    Wei, Xudong
    Li, Yuhua
    Jiang, Zhongxing
    Li, Yiqing
    Du, Xin
    Yang, Linhua
    Lin, Lie
    Wang, Jishi
    Yao, Yazhou
    Hu, Xiaoping
    Lan, Jianping
    Deng, Xiuzhi
    Chen, Tong
    Feng, Xianqi
    Li, Dengju
    Hou, Ming
    Fu, Rong
    Huang, Siyong
    Wang, Jingbo
    Du, Xin
    Yang, Hui
    Yang, Haiping
    Jiang, Yingzhi
    Wang, Zhijie
    Li, Deng
    Liu, Bing
    Kang, Ning
    Zhuang, Yulei
    Zhang, Yingjun
    BLOOD, 2023, 142
  • [43] Hypomethylating agent and venetoclax with FLT3 inhibitor "triplet" therapy in older/unfit patients with FLT3 mutated AML
    Yilmaz, Musa
    Kantarjian, Hagop
    Short, Nicholas J.
    Reville, Patrick
    Konopleva, Marina
    Kadia, Tapan
    DiNardo, Courtney
    Borthakur, Gautam
    Pemmaraju, Naveen
    Maiti, Abhishek
    Jabbour, Elias
    Jain, Nitin
    Issa, Ghayas
    Takahashi, Koichi
    Sasaki, Koji
    Ohanian, Maro
    Pierce, Sherry
    Tang, Guillin
    Loghavi, Sanam
    Patel, Keyur
    Wang, Sa A.
    Garcia-Manero, Guillermo
    Andreeff, Michael
    Ravandi, Farhad
    Daver, Naval
    BLOOD CANCER JOURNAL, 2022, 12 (05)
  • [44] Examination of the FLT3 and NPM1 mutational status in patients with acute myeloid leukemia from southeastern Poland
    Koczkodaj, Dorota
    Zmorzynski, Szymon
    Michalak-Wojnowska, Malgorzata
    Wasik-Szczepanek, Ewa
    Filip, Agata A.
    ARCHIVES OF MEDICAL SCIENCE, 2016, 12 (01) : 120 - 128
  • [45] LT-171-861, a novel FLT3 inhibitor, shows excellent preclinical efficacy for the treatment of FLT3 mutant acute myeloid leukemia
    Yu, Zhou
    Du, Jiaying
    Hui, Hui
    Kan, Shaoxin
    Huo, Tongxin
    Zhao, Kai
    Wu, Tao
    Guo, Qinglong
    Lu, Na
    THERANOSTICS, 2021, 11 (01): : 93 - 106
  • [46] Pre-transplant FLT3/ITD status predicts outcome in FLT3-mutated acute myeloid leukemia following allogeneic stem cell transplantation
    Grzegorz Helbig
    Anna Koclęga
    Agata Wieczorkiewicz-Kabut
    Krzysztof Woźniczka
    Anna Kopińska
    Kinga Boral
    Iwona Grygoruk-Wiśniowska
    Małgorzata Stachowicz
    Agnieszka Karolczyk
    Annals of Hematology, 2020, 99 : 1845 - 1853
  • [47] Efficacy of FLT3 and IDH1/2 inhibitors in patients with acute myeloid leukemia previously treated with venetoclax
    Bewersdorf, Jan Philipp
    Shallis, Rory M.
    Derkach, Andriy
    Goldberg, Aaron D.
    Stein, Anthony
    Stein, Eytan M.
    Marcucci, Guido
    Zeidan, Amer M.
    Shimony, Shai
    DeAngelo, Daniel J.
    Stone, Richard M.
    Aldoss, Ibrahim
    Ball, Brian J.
    Stahl, Maximilian
    LEUKEMIA RESEARCH, 2022, 122
  • [48] FLT3 Tyrosine Kinase Inhibitors for the Treatment of Fit and Unfit Patients with FLT3-Mutated AML: A Systematic Review
    Loschi, Michael
    Sammut, Rinzine
    Chiche, Edmond
    Cluzeau, Thomas
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (11)
  • [49] Practical tips for managing FLT3 mutated acute myeloid leukemia with midostaurin
    Arnan Sangerman, Montserrat
    Fernandez Moreno, Ainhoa
    Garcia Quintana, Antonio
    Garcia-Vidal, Carolina
    Olave Rubio, Maria Teresa
    Tormo Diaz, Maria Del Mar
    Vendranas, Meritxell
    Rodriguez Macias, Gabriela
    EXPERT REVIEW OF HEMATOLOGY, 2022, 15 (03) : 203 - 214
  • [50] Pre-transplant FLT3/ITD status predicts outcome in FLT3-mutated acute myeloid leukemia following allogeneic stem cell transplantation
    Helbig, Grzegorz
    Koclega, Anna
    Wieczorkiewicz-Kabut, Agata
    Wozniczka, Krzysztof
    Kopinska, Anna
    Boral, Kinga
    Grygoruk-Wisniowska, Iwona
    Stachowicz, Malgorzata
    Karolczyk, Agnieszka
    ANNALS OF HEMATOLOGY, 2020, 99 (08) : 1845 - 1853
12345