Peak Width of Skeletonized Mean Diffusivity: A Neuroimaging Marker for White Matter Injury

被引：32

作者：

Zotin, Maria Clara Zanon ^{[1
,2
]}

Yilmaz, Pinar ^{[1
,3
,4
]}

Sveikata, Lukas ^{[1
,5
,6
]}

Schoemaker, Dorothee ^{[1
]}

van Veluw, Susanne J. ^{[1
]}

Etherton, Mark R. ^{[1
]}

Charidimou, Andreas ^{[1
]}

Greenberg, Steven M. ^{[1
]}

Duering, Marco ^{[7
,8
]}

Viswanathan, Anand ^{[1
]}

机构：

[1] Harvard Med Sch, Massachusetts Gen Hosp, J Philip Kistler Stroke Res Ctr, Dept Neurol, Boston, MA 02115 USA

[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Ctr Imaging Sci & Med Phys, Dept Med Imaging Hematol & Clin Oncol, 3900 Ten Catao Roxo St, BR-14015010 Ribeirao Preto, SP, Brazil

[3] Erasmus MC, Dept Epidemiol & Radiol, Rotterdam, Netherlands

[4] Erasmus MC, Dept Nucl Med, Rotterdam, Netherlands

[5] Univ Geneva, Geneva Univ Hosp, Fac Med, Dept Clin Neurosci,Div Neurol, Geneva, Switzerland

[6] Lithuanian Univ Hlth Sci, Inst Cardiol, Med Acad, Kaunas, Lithuania

[7] Univ Basel, Med Image Anal Ctr MIAC AG, Dept Biomed Engn, Basel, Switzerland

[8] Univ Basel, Dept Biomed Engn, Quant Biomed Imaging Grp qbig, Basel, Switzerland

来源：

RADIOLOGY | 2023年 / 306卷 / 03期

基金：

美国国家卫生研究院; 瑞士国家科学基金会;

关键词：

SMALL VESSEL DISEASE; MRI; INTEGRITY; EVOLUTION;

D O I：

10.1148/radiol.212780

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A leading cause of white matter (WM) injury in older individuals is cerebral small vessel disease (SVD). Cerebral SVD is the most prevalent vascular contributor to cognitive impairment and dementia. Therapeutic progress for cerebral SVD and other WM dis-orders depends on the development and validation of neuroimaging markers suitable as outcome measures in future interventional trials. Diffusion-tensor imaging (DTI) is one of the best-suited MRI techniques for assessing the extent of WM damage in the brain. But the optimal method to analyze individual DTI data remains hindered by labor-intensive and time-consuming processes. Peak width of skeletonized mean diffusivity (PSMD), a recently developed fast, fully automated DTI marker, was designed to quan-tify the WM damage secondary to cerebral SVD and reflect related cognitive impairment. Despite its promising results, knowledge about PSMD is still limited in the radiologic community. This focused review provides an overview of the technical details of PSMD while synthesizing the available data on its clinical and neuroimaging associations. From a critical expert viewpoint, the au-thors discuss the limitations of PSMD and its current validation status as a neuroimaging marker for vascular cognitive impairment. Finally, they point out the gaps to be addressed to further advance the field.(c) RSNA, 2023

引用

页数：13

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