The immune microenviroment in somatotropinomas: from biology to personalized and target therapy

被引：10
作者：
Chiloiro, Sabrina [1 ,2 ]
De Marinis, Laura [1 ,2 ]
机构：
[1] Fdn Policlin Univ A Gemelli IRCCS, UOC Endocrinol & Diabetol, I-00168 Rome, Italy
[2] Univ Cattolica Sacro Cuore, Dept Translat Med & Surg, I-00168 Rome, Italy
来源：
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS | 2023年 / 24卷 / 02期
关键词：
Acromegaly; Pituitary; Immunotherapy; Target therapy; AGGRESSIVE PITUITARY-TUMORS; ENDOTHELIAL GROWTH-FACTOR; BLOOD MONONUCLEAR-CELLS; IN-VITRO; CYTOKINE PRODUCTION; HORMONE-SECRETION; EUROPEAN-SOCIETY; DENDRITIC CELLS; SERUM PROLACTIN; EXPRESSION;
D O I：
10.1007/s11154-022-09782-1
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Pituitary tumors are rare neoplasms, with a heterogeneous biological and clinical behavior, due to their clinical course, local invasive growth, resistance to conventional therapies and the risk of disease progression. Recent studies on tumor microenvironment (TME) provided new knowledge on the biology of these neoplasia, that may explain the different phenotypes of these tumors and suggest new biomarkers able to predict the prognosis and the treatment outcome. The identification of molecular markers that act as targets for biological therapies may open new perspectives in the medical treatments of aggressive pituitary tumors.In this paper, we will review data of TME and target therapies in somatotropinomas.
引用
收藏
页码：283 / 295
页数：13
相关论文
共 119 条
  • [1] 25-hydroxyvitamin D Correlation with Prolactin Levels and Adenoma Size in Female Patients with Newly Diagnosed Prolactin Secreting Adenoma
    Aboelnaga, Mohamed M.
    Abdullah, Nahed
    El Shaer, Mostafa
    [J]. ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS, 2017, 17 (03) : 219 - 225
  • [2] Pharmacological induction of tolerogenic dendritic cells and regulatory T cells
    Adorini, L
    Giarratana, N
    Penna, G
    [J]. SEMINARS IN IMMUNOLOGY, 2004, 16 (02) : 127 - 134
  • [3] History and perspectives of pituitary folliculo-stellate cell research
    Allaerts, W
    Vankelecom, H
    [J]. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2005, 153 (01) : 1 - 12
  • [4] Autophagy-mediated neuroprotection induced by octreotide in an ex vivo model of early diabetic retinopathy
    Amato, Rosario
    Catalani, Elisabetta
    Dal Monte, Massimo
    Cammalleri, Maurizio
    Di Renzo, Ilaria
    Perrotta, Aistiana
    Cervia, Davide
    Casini, Giovanni
    [J]. PHARMACOLOGICAL RESEARCH, 2018, 128 : 167 - 178
  • [5] VEGF as a Survival Factor in Ex Vivo Models of Early Diabetic Retinopathy
    Amato, Rosario
    Biagioni, Martina
    Cammalleri, Maurizio
    Dal Monte, Massimo
    Casini, Giovanni
    [J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2016, 57 (07) : 3066 - 3076
  • [6] INTERLEUKIN INVOLVEMENT IN ANTERIOR-PITUITARY CELL-GROWTH REGULATION - EFFECTS OF IL-2 AND IL-6
    ARZT, E
    BURIC, R
    STELZER, G
    STALLA, J
    SAUER, J
    RENNER, U
    STALLA, GK
    [J]. ENDOCRINOLOGY, 1993, 132 (01) : 459 - 467
  • [7] From pituitary adenoma to pituitary neuroendocrine tumor (PitNET): an International Pituitary Pathology Club proposal
    Asa, S. L.
    Casar-Borota, O.
    Chanson, P.
    Delgrange, E.
    Earls, P.
    Ezzat, S.
    Grossman, A.
    Ikeda, H.
    Inoshita, N.
    Karavitaki, N.
    Korbonits, M.
    Laws, E. R., Jr.
    Lopes, M. B.
    Maartens, N.
    McCutcheon, I. E.
    Mete, O.
    Nishioka, H.
    Raverot, G.
    Roncaroli, F.
    Saeger, W.
    Syro, L. V.
    Vasiljevic, A.
    Villa, C.
    Wierinckx, A.
    Trouillas, J.
    [J]. ENDOCRINE-RELATED CANCER, 2017, 24 (04) : C5 - C8
  • [8] The tumor microenvironment at a glance
    Balkwill, Frances R.
    Capasso, Melania
    Hagemann, Thorsten
    [J]. JOURNAL OF CELL SCIENCE, 2012, 125 (23) : 5591 - 5596
  • [9] A NOVEL FAMILY OF GROWTH-FACTOR RECEPTORS - A COMMON BINDING DOMAIN IN THE GROWTH-HORMONE, PROLACTIN, ERYTHROPOIETIN AND IL-6 RECEPTORS, AND THE P75 IL-2 RECEPTOR BETA-CHAIN
    BAZAN, JF
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 164 (02) : 788 - 795
  • [10] Role of tyrosine kinase inhibitors in the treatment of pituitary tumours: from bench to bedside
    Ben-Shlomo, Anat
    Cooper, Odelia
    [J]. CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY, 2017, 24 (04) : 301 - 305
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