The immune microenviroment in somatotropinomas: from biology to personalized and target therapy

被引：13
作者：
Chiloiro, Sabrina [1 ,2 ]
De Marinis, Laura [1 ,2 ]
机构：
[1] Fdn Policlin Univ A Gemelli IRCCS, UOC Endocrinol & Diabetol, I-00168 Rome, Italy
[2] Univ Cattolica Sacro Cuore, Dept Translat Med & Surg, I-00168 Rome, Italy
来源：
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS | 2023年 / 24卷 / 02期
关键词：
Acromegaly; Pituitary; Immunotherapy; Target therapy; AGGRESSIVE PITUITARY-TUMORS; ENDOTHELIAL GROWTH-FACTOR; BLOOD MONONUCLEAR-CELLS; IN-VITRO; CYTOKINE PRODUCTION; HORMONE-SECRETION; EUROPEAN-SOCIETY; DENDRITIC CELLS; SERUM PROLACTIN; EXPRESSION;
D O I：
10.1007/s11154-022-09782-1
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Pituitary tumors are rare neoplasms, with a heterogeneous biological and clinical behavior, due to their clinical course, local invasive growth, resistance to conventional therapies and the risk of disease progression. Recent studies on tumor microenvironment (TME) provided new knowledge on the biology of these neoplasia, that may explain the different phenotypes of these tumors and suggest new biomarkers able to predict the prognosis and the treatment outcome. The identification of molecular markers that act as targets for biological therapies may open new perspectives in the medical treatments of aggressive pituitary tumors.In this paper, we will review data of TME and target therapies in somatotropinomas.
引用
收藏
页码：283 / 295
页数：13
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