Brief Report: Plasma Leptin and Mealtime Feeding Behaviors Among Children with Autism Spectrum Disorder: A Pilot Study

被引：4

作者：

Dhaliwal, Khushmol K. ^{[1
]}

Avedzi, Hayford M. ^{[1
]}

Richard, Caroline ^{[2
]}

Zwaigenbaum, Lonnie ^{[1
]}

Haqq, Andrea M. ^{[1
,2
]}

机构：

[1] Univ Alberta, Dept Pediat, Fac Med & Dent, 1C4 Walter C Mackenzie Hlth Sci Ctr, 8440-112 St NW, Edmonton, AB T6G 2B7, Canada

[2] Univ Alberta, Dept Agr Food & Nutr Sci, Fac Agr Life & Environm Sci, Edmonton, AB, Canada

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2023年 / 53卷 / 12期

关键词：

Autism; Obesity; Appetite regulating hormones; Mealtime behaviors; OBESITY; INSULIN; ASSOCIATION; RESISTANCE; DIET;

D O I：

10.1007/s10803-022-05581-4

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

We examined the relationship between weight status, appetite regulating hormones, and mealtime behaviors among children, (5-12 years old), diagnosed with Autism Spectrum Disorder (ASD) in a cross-sectional study. All (N = 21) completed anthropometry measurements and (n = 18) provided blood samples for hormone analysis. Mealtime behavior, dietary, physical activity, puberty stage, and social impairment data were collected. Under fasting conditions, overweight/obese (OWOB) participants, (n = 6), had higher leptin concentrations (p < 0.02) and more feeding challenges (p < 0.05) than normal weight (n = 15). Higher leptin levels and disruptions in mealtime behaviors may exist among OWOB children in this study. Future longitudinal studies that examine appetite regulating hormones and mealtime behaviors may inform our understanding of the role of these markers in the development of obesity in ASD.

引用

页码：4929 / 4936

页数：8

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