Diminished ovarian reserve is associated with metabolic disturbances and hyperhomocysteinemia in women with infertility

Background: To distinguish the metabolic profile between women with diminished ovarian reserve (DOR) and those with normal ovarian reserve (NOR).Methods: In this retrospective study, we enrolled 524 women under the age of 40 who were experiencing infertility: 261 in the DOR group and 263 in the NOR group. Physical characteristics and metabolic parameters were compared between these two groups.Results: Women with DOR exhibited a higher propensity for elevated parameters including body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), as well as heightened serum levels of homocysteine (Hcy), triglycerides (TG), low-density lipoprotein (LDL), and triglyceride-glucose (TyG) index, while concurrently experiencing reduced serum levels of high-density lipoprotein (HDL) (P < 0.05). Furthermore, the incidence rates of TG >= 1.7 mmol/L, hyperhomocysteinemia (HHcy), BMI >= 25 kg/m(2), SBP/DBP >= 130/85 mmHg, and metabolic syndrome (MS) were significantly elevated within the DOR group as compared to the NOR group (P < 0.05).Conclusion: The prevalence of metabolic disturbances and HHcy were notably elevated in women with infertility and DOR compared to those with NOR.