Claudin-5 overexpression correlates with proliferation and migration in gastric cancer

被引：2

作者：

Li, Sandang ^{[1
]}

Zhang, Taizhe ^{[1
]}

Xie, Fuchen ^{[1
]}

Du, Zhaohui ^{[1
]}

Du, Jie ^{[1
]}

Wang, Zhenjie ^{[1
]}

机构：

[1] Bengbu Med Coll, Affiliated Hosp 1, Dept Emergency Surg, 287 Changhuai Rd, Bengbu 233000, Anhui, Peoples R China

来源：

MOLECULAR & CELLULAR TOXICOLOGY | 2024年 / 20卷 / 04期

关键词：

Gastric cancer; Claudin-5; Proliferation; Migration; NODE-METASTASIS; EXPRESSION;

D O I：

10.1007/s13273-023-00407-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

BackgroundGastric cancer (GC) is a common malignant tumor of the digestive tract. Claudin-5 is upregulated in GC tumor tissues, but its effect on GC is imprecise. In this study, we analyzed the influence of claudin-5 on GC.ObjectivesTo investigate the effect of Claudin-5 on Gastric cancer (GC).ResultsWe confirmed that the content of claudin-5 in MKN45 and AGS cells was boosted by Claudin-5 transfection, but decreased by si-Claudin-5 transfection. Besides, claudin-5 overexpression expedited GC cells proliferation, migration and invasion, but repressed GC cells apoptosis. Silencing claudin-5 curbed tumor growth in vivo.ConclusionClaudin-5 overexpression expedited GC cells proliferation, migration and invasion, but repressed GC cells apoptosis. Claudin-5 expedited the proliferation of GC cells.Claudin-5 repressed GC cells apoptosis.Claudin-5 facilitated the migration and invasion of GC cells.Silencing claudin-5 curbed tumor growth in vivo.

引用

页码：969 / 977

页数：9

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