Mesenchymal stem cells influence monocyte/macrophage phenotype: Regulatory mode and potential clinical applications

被引：17
作者：
Lu, Dejin [1 ]
Jiao, Xue [1 ]
Jiang, Wenjian [1 ]
Yang, Li [1 ]
Gong, Qian [1 ]
Wang, Xiaobin [2 ]
Wei, Minjie [1 ]
Gong, Shiqiang [1 ]
机构：
[1] China Med Univ, Sch Pharm, Dept Pharmacol, Shenyang 110122, Peoples R China
[2] China Med Univ, Ctr Reprod Med, Shengjing Hosp, Shenyang 110004, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 165卷
关键词：
Mesenchymal stem cells; M1/M2; phenotype; Monocytes/macrophages; Phagocytosis; Paracrine action; Mitochondrial transfer; ACUTE LUNG INJURY; STROMAL CELLS; MITOCHONDRIAL TRANSFER; MACROPHAGE DIFFERENTIATION; TROPHIC MACROPHAGES; IN-VITRO; B-CELLS; MONOCYTES; TRANSPLANTATION; MICROVESICLES;
D O I：
10.1016/j.biopha.2023.115042
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Mesenchymal stem cells (MSCs) are pluripotent stem cells derived from a variety of tissues, such as umbilical cord, fat, and bone marrow. Today, MSCs are widely recognized for their prominent anti-inflammatory properties in a variety of acute and chronic inflammatory diseases. In inflammatory diseases, monocytes/macrophages are an important part of the innate immune response in the body, and the alteration of the inflammatory phenotype plays a crucial role in the secretion of pro-inflammatory/anti-inflammatory factors, the repair of injured sites, and the infiltration of inflammatory cells. In this review, starting from the effect of MSCs on the monocyte/macrophage phenotype, we have outlined in detail the process by which MSCs influence the transformation of the monocyte/macrophage inflammatory phenotype, emphasizing the central role of monocytes/ macrophages in MSC-mediated anti-inflammatory and damage site repair. MSCs are phagocytosed by monocytes/macrophages in various physiological states, the paracrine effect of MSCs and mitochondrial transfer of MSCs to macrophages to promote the transformation of monocytes/macrophages into anti-inflammatory phenotypes. We also review the clinical applications of the MSCs-monocytes/macrophages system and describe novel pathways between MSCs and tissue repair, the effects of MSCs on the adaptive immune system, and the effects of energy metabolism levels on monocyte/macrophage phenotypic changes.
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页数：9
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