Enantioselective cyanation of propargylic C-H bonds via cooperative photoredox and copper catalysis

被引：15
|
作者：
Deng, Yunshun [1 ]
Lu, Ronghua [2 ,3 ]
Chen, Pinhong [2 ,3 ]
Liu, Guosheng [1 ,2 ,3 ]
机构：
[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China
[2] Chinese Acad Sci, State Key Lab Organometall Chem, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem,Univ Chinese Acad Sci, Shanghai 200032, Peoples R China
[3] Chinese Acad Sci, Shanghai Hongkong Joint Lab Chem Synth, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem,Univ Chinese Acad Sci, Shanghai 200032, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 31期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
C-H bond - Condition - Copper catalysis - Copper catalyzed - Cyanation - Enantioselective - Photoredox catalysis - Propargyl;
D O I：
10.1039/d3cc00410d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein, we report an enantioselective cyanation of propargylic C-H bonds by combining photoredox catalysis with a copper-catalyzed radical relay in which the propargylic radical was generated by an intramolecular 1,5-HAT process. This reaction provides easy access to optically pure propargyl nitrile compounds under mild conditions.
引用
收藏
页码：4656 / 4659
页数：4
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