Efficacy of Peripheral Nerve Stimulation with a High Frequency Electromagnetic Coupled (HF-EMC) Powered Implanted Receiver in Treating Different Pain Targets/Neuralgias

Introduction: Chronic pain is a significant global public health problem. Peripheral nerve stimulation (PNS) has been gaining popularity in recent years as it is effective, safe and less invasive than surgery for the treatment of chronic pain. The authors aimed to document and share a collection of patient-reported pain scores before and after implanting a percutaneous PNS lead/s with an external wireless generator at various target nerves.Methods: The authors designed a retrospective study, reviewing electronic medical records. Statistical analysis was performed using SPSS 26; p-value < 0.05 was considered significant.Results: The mean baseline pain scores of 57 patients have reduced significantly after the procedure at different follow-up durations. Target nerves included genicular nerves, superior cluneal nerves, posterior tibial nerve +/- sural nerve, middle cluneal nerves, radial and ulnar nerves and right common peroneal nerve. In the one-month follow-up group, mean pain score was reduced from 7.44 +/- 1.48 pre-procedure to 1.6 +/- 1.49, from 7.42 +/- 1.5 pre-procedure to 1.6 +/- 1.5 7.42 at 3 months, from 7.52 +/- 1.5 to 1.72 +/- 1.57 at 6 months, from 7.41 +/- 1.53 to 1.7 +/- 1.55 at 9 months, from 7.41 +/- 1.58 to 1.76 +/- 1.63 at 12 months, from 7.38 +/- 1.59 to 1.69 +/- 1.56 at 15 months and from 7.5 +/- 1.7 to 1.45 +/- 1.57 at 24 months (p < 0.001). Patients also reported significant reduction in morphine milliequivalent, pre-procedure MME 47.75 +/- 452.5 to 37.92 +/- 43.51 at 6 months (p = 0.002, N = 57), pre-procedure MME 42.72 +/- 43.19 to 30.38 +/- 41.62 at 12 months (p = 0.003, N = 42), and pre-procedure MME 41.2 +/- 46.12 to 21.19 +/- 40.88 at 24 months (p < 0.001, N = 27). The only complications occurred post procedure with 2 patients receiving an explant and 1 patient receiving a lead migration.Conclusion: PNS has been shown to be safe and effective in treating chronic pain at different sites with sustained pain relief for up to 24 months. This study is unique in providing long-term follow-up data.