Association of anorexia/appetite loss with malnutrition and mortality in older populations: A systematic literature review

被引:50
作者
Fielding, Roger A. [1 ]
Landi, Francesco [2 ]
Smoyer, Karen E. [3 ]
Tarasenko, Lisa [4 ]
Groarke, John [5 ]
机构
[1] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Nutr Exercise Physiol & Sarcopenia Lab, 711 Washington St, Boston, MA 02155 USA
[2] Fdn Policlin Univ Agostino Gemelli IRCSS, Rome, Italy
[3] Curo, Envis Pharm Grp, Fairfield, CT USA
[4] Pfizer Inc, New York, NY USA
[5] Pfizer Inc, Cambridge, MA USA
关键词
anorexia; appetite loss; malnutrition; mortality; prevalence; systematic literature review; QUALITY-OF-LIFE; NUTRITIONAL ASSESSMENT MNA; RECEIVING HOME-CARE; ELDERLY-PATIENTS; POOR APPETITE; COMMUNITY; ANOREXIA; ADULTS; RISK; UNDERNUTRITION;
D O I
10.1002/jcsm.13186
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Anorexia/appetite loss in older subjects is frequently underrecognized in clinical practice, which may reflect deficient understanding of clinical sequelae. Therefore, we performed a systematic literature review to assess the morbidity and mortality burden of anorexia/appetite loss in older populations. Following PRISMA guidelines, searches were run (1 January 2011 to 31 July 2021) in PubMed, Embase (R) and Cochrane databases to identify English language studies of adults aged >= 65 years with anorexia/appetite loss. Two independent reviewers screened titles, abstracts and full text of identified records against pre-defined inclusion/exclusion criteria. Population demographics were extracted alongside risk of malnutrition, mortality and other outcomes of interest. Of 146 studies that underwent full-text review, 58 met eligibility criteria. Most studies were from Europe (n = 34; 58.6%) or Asia (n = 16; 27.6%), with few (n = 3; 5.2%) from the United States. Most were conducted in a community setting (n = 35; 60.3%), 12 (20.7%) were inpatient based (hospital/rehabilitation ward), 5 (8.6%) were in institutional care (nursing/care homes) and 7 (12.1%) were in other (mixed or outpatient) settings. One study reported results separately for community and institutional settings and is counted in both settings. Simplified Nutritional Appetite Questionnaire (SNAQ Simplified, n = 14) and subject-reported appetite questions (n = 11) were the most common methods used to assess anorexia/appetite loss, but substantial variability in assessment tools was observed across studies. The most commonly reported outcomes were malnutrition and mortality. Malnutrition was assessed in 15 studies, with all reporting a significantly higher risk of malnutrition in older individuals with anorexia/appetite loss (vs. without) regardless of country or healthcare setting (community n = 9, inpatient n = 2, institutional n = 3, other n = 2). Of 18 longitudinal studies that assessed mortality risk, 17 (94%) reported a significant association between anorexia/appetite loss and mortality regardless of either healthcare setting (community n = 9, inpatient n = 6, institutional n = 2) or method used to assess anorexia/appetite loss. This association between anorexia/appetite loss and mortality was observed in cohorts with cancer (as expected) but was also observed in older populations with a range of comorbid conditions other than cancer. Overall, our findings demonstrate that, among individuals aged >= 65 years, anorexia/appetite loss is associated with increased risk of malnutrition, mortality and other negative outcomes across community, care home and hospital settings. Such associations warrant efforts to improve and standardize screening, detection, assessment and management of anorexia/appetite loss in older adults.
引用
收藏
页码:706 / 729
页数:24
相关论文
共 86 条
[1]   THE EUROPEAN-ORGANIZATION-FOR-RESEARCH-AND-TREATMENT-OF-CANCER QLQ-C30 - A QUALITY-OF-LIFE INSTRUMENT FOR USE IN INTERNATIONAL CLINICAL-TRIALS IN ONCOLOGY [J].
AARONSON, NK ;
AHMEDZAI, S ;
BERGMAN, B ;
BULLINGER, M ;
CULL, A ;
DUEZ, NJ ;
FILIBERTI, A ;
FLECHTNER, H ;
FLEISHMAN, SB ;
DEHAES, JCJM ;
KAASA, S ;
KLEE, M ;
OSOBA, D ;
RAZAVI, D ;
ROFE, PB ;
SCHRAUB, S ;
SNEEUW, K ;
SULLIVAN, M ;
TAKEDA, F .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (05) :365-376
[2]  
Aprahamian I., 2022, 15 INT C CACHEXIA SA
[3]   Risk factors for fall-related injuries among community-dwelling men and women over 70 years of age, based on social cognitive theory: results from a population study [J].
Arkkukangas, Marina ;
Eriksson, Hans-Georg ;
Dension, Eva .
EUROPEAN JOURNAL OF PHYSIOTHERAPY, 2021, 23 (04) :221-226
[4]   Symptom Burden in Patients With Home Care Who Are at Risk for Malnutrition: A Cross-Sectional Study [J].
Berggren, Erika ;
Strang, Peter ;
Orrevall, Ylva ;
Olin, Ann Odlund ;
Tornkvist, Lena .
JOURNAL OF PALLIATIVE CARE, 2020, 35 (02) :103-109
[5]  
Bruera E, 1991, J Palliat Care, V7, P6
[6]   Prevalence of low protein intake in 80+-year-old community-dwelling adults and association with dietary patterns and modifiable risk factors: a cross-sectional study [J].
Buhl, Sussi F. ;
Beck, Anne M. ;
Christensen, Britt ;
Kock, Gry ;
Boyle, Eleanor ;
Caserotti, Paolo .
BRITISH JOURNAL OF NUTRITION, 2022, 127 (02) :266-277
[7]   Predictors of mortality in people with late-life depression: A retrospective cohort study [J].
Cai, Wa ;
Mueller, Christoph ;
Shetty, Hitesh ;
Perera, Gayan ;
Stewart, Robert .
JOURNAL OF AFFECTIVE DISORDERS, 2020, 266 :695-701
[8]   The Patient-Reported Outcomes Measurement Information System (PROMIS) developed and tested its first wave of adult self-reported health outcome item banks: 2005-2008 [J].
Cella, David ;
Riley, William ;
Stone, Arthur ;
Rothrock, Nan ;
Reeve, Bryce ;
Yount, Susan ;
Amtmann, Dagmar ;
Bode, Rita ;
Buysse, Daniel ;
Choi, Seung ;
Cook, Karon ;
DeVellis, Robert ;
DeWalt, Darren ;
Fries, James F. ;
Gershon, Richard ;
Hahn, Elizabeth A. ;
Lai, Jin-Shei ;
Pilkonis, Paul ;
Revicki, Dennis ;
Rose, Matthias ;
Weinfurt, Kevin ;
Hays, Ron .
JOURNAL OF CLINICAL EPIDEMIOLOGY, 2010, 63 (11) :1179-1194
[9]  
Cleeland CS, 2000, CANCER-AM CANCER SOC, V89, P1634, DOI 10.1002/1097-0142(20001001)89:7<1634::AID-CNCR29>3.0.CO
[10]  
2-V