Isolation and cytotoxic activities of undescribed iridoid and xanthone glycosides from Centaurium erythraea Rafn. (Gentianaceae)

被引：14

作者：

Aksit, Hueseyin ^{[1
]}

Gozcu, Sefa ^{[2
]}

Altay, Ahmet ^{[3
]}

机构：

[1] Erzincan Binali Yildirim Univ, Fac Pharm, Analyt Chem Dept, Erzincan, Turkiye

[2] Erzincan Binali Yildirim Univ, Fac Pharm, Dept Pharmacognosy, Erzincan, Turkiye

[3] Erzincan Binali Yildirim Univ, Fac Art & Sci, Chem Dept, Erzincan, Turkiye

来源：

PHYTOCHEMISTRY | 2023年 / 205卷

关键词：

Centaurium erythraea; Gentianaceae; Xanthones; Iridoids; Cytotoxic activity; ACID; GENTIOPICROSIDE; CARBOHYDRATE; SECOIRIDOIDS; GLUCOSIDES; METABOLISM;

D O I：

10.1016/j.phytochem.2022.113484

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Centaurium erythraea Rafn. (Gentianaceae) is used in internal traditional therapy as an anthelmintic, hypotensive, antipyretic, and antidiabetic. It is used externally for the treatment of wounds. Ursolic acid, maslinic acid, secologanin, secologanin dimethyl acetal, centauroside A, erythraeaxanthone I, erythraeaxanthone II, and demethyleustomin were isolated from aerial parts of Centaurium erythraea and were identified using spectro-scopic methods, including NMR and mass spectrometry. The cytotoxic potency of undescribed compounds was evaluated by the XTT assay against human breast cancer MCF-7, MDA-MB-453 and mouse fibroblast 3T3-L1 cell lines. Erythraeaxanthone II was found to have the most potent cytotoxic activity.

引用

页数：7

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