N6-methyladenosine-mediated gene regulation and therapeutic implications

被引:55
|
作者
Liu, Yujiao [1 ]
Yang, Dan [1 ]
Liu, Tao [1 ]
Chen, Jianjun [2 ]
Yu, Jianhua [1 ,3 ,4 ]
Yi, Ping [1 ]
机构
[1] Chongqing Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 3, Chongqing 401120, Peoples R China
[2] City of Hope, Beckman Res Inst, Dept Syst Biol, Los Angeles, CA 91010 USA
[3] City Hope Natl Med Ctr, Hematol Malignancies Res Inst, Los Angeles, CA 91010 USA
[4] City Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplantat, Los Angeles, CA 91010 USA
关键词
MESSENGER-RNA; HEPATOCELLULAR-CARCINOMA; MOLECULAR-MECHANISMS; PHASE-SEPARATION; SELF-RENEWAL; N-6-METHYLADENOSINE; FTO; METHYLATION; EXPRESSION; TRANSLATION;
D O I
10.1016/j.molmed.2023.03.005
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
N6-methyladenosine (m6A) RNA methylation is the most abundant form of mRNA modification in eukaryotes and is at the front line of biological and biomedical re-search. This dynamic and reversible m6A RNA modification determines the fates of modified RNA molecules at the post-transcriptional level, affecting almost all important biological processes. Notably, m6A is also involved in chromatin and transcriptional regulation, while m6A dysregulation is implicated in various dis-eases. Here, we review current knowledge of post-transcriptional and transcrip-tional regulatory mechanisms involving m6A modification. We also discuss their involvement in the occurrence and development of diseases, including cancer, as well as potential theranostic targets, in hope of facilitating the translation of preclinical findings to the clinic.
引用
收藏
页码:454 / 467
页数:14
相关论文
共 50 条
  • [1] N6-methyladenosine-mediated overexpression of TREM-1 is associated with periodontal disease
    Burra Anand, Deepika
    Ramamurthy, Jaiganesh
    Kannan, Balachander
    Jayaseelan, Vijayashree Priyadharsini
    Arumugam, Paramasivam
    ODONTOLOGY, 2024, : 834 - 843
  • [2] Novel Insights into Adipogenesis from the Perspective of Transcriptional and RNA N6-Methyladenosine-Mediated Post-Transcriptional Regulation
    Song, Tongxing
    Yang, Yang
    Jiang, Siwen
    Peng, Jian
    ADVANCED SCIENCE, 2020, 7 (21)
  • [3] Making Changes: N6-Methyladenosine-Mediated Decay Drives the Endothelial-to-Hematopoietic Transition
    Hsu, Phillip J.
    He, Chuan
    BIOCHEMISTRY, 2017, 56 (46) : 6077 - 6078
  • [4] Multilevel regulation of N6-methyladenosine RNA modifications: Implications in tumorigenesis and therapeutic opportunities
    Feng, Lili
    Du, Rongrong
    Chang, Baitong
    Li, Min
    Tian, Jie
    Wang, Shengjun
    GENES & DISEASES, 2023, 10 (05) : 1969 - 1981
  • [5] N6-methyladenosine-mediated feedback regulation of abscisic acid perception via phase-separated ECT8 condensates in Arabidopsis
    Wu, Xiaowei
    Su, Tingting
    Zhang, Songyao
    Zhang, Yu
    Wong, Chui Eng
    Ma, Jinqi
    Shao, Yanlin
    Hua, Changmei
    Shen, Lisha
    Yu, Hao
    NATURE PLANTS, 2024, 10 (03) : 469 - 482
  • [6] Abnormal expression of CDC25C in NSCLC is influenced by transcriptional and RNA N6-methyladenosine-mediated post-transcriptional regulation
    Zheng, Yuxin
    Wang, Kefeng
    Mao, Wenli
    Zhang, Guojun
    Han, Xiaomin
    Li, Hualin
    Wang, Yukun
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2025, 66 (04)
  • [7] Identification of an N6-methyladenosine-mediated positive feedback loop that promotes Epstein-Barr virus infection
    Dai, Dan-Ling
    Li, Xingyang
    Wang, Lin
    Xie, Chu
    Jin, Yanan
    Zeng, Mu-Sheng
    Zuo, Zhixiang
    Xia, Tian-Liang
    Journal of Biological Chemistry, 2021, 296
  • [8] Identification of an N6-methyladenosine-mediated positive feedback loop that promotes Epstein-Barr virus infection
    Dai, Dan-Ling
    Li, Xingyang
    Wang, Lin
    Xie, Chu
    Jin, Yanan
    Zeng, Mu-Sheng
    Zuo, Zhixiang
    Xia, Tian-Liang
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2021, 296
  • [9] N6-methyladenosine-mediated LDHA induction potentiates chemoresistance of colorectal cancer cells through metabolic reprogramming
    Zhang, Kun
    Zhang, Tao
    Yang, Yuhan
    Tu, Wenling
    Huang, Hongbin
    Wang, Yujun
    Chen, Yuzhuo
    Pan, Kejian
    Chen, Zhuojia
    THERANOSTICS, 2022, 12 (10): : 4802 - 4817
  • [10] N6-methyladenosine-mediated feedback regulation of abscisic acid perception via phase-separated ECT8 condensates in Arabidopsis
    Xiaowei Wu
    Tingting Su
    Songyao Zhang
    Yu Zhang
    Chui Eng Wong
    Jinqi Ma
    Yanlin Shao
    Changmei Hua
    Lisha Shen
    Hao Yu
    Nature Plants, 2024, 10 : 469 - 482