N6-methyladenosine-mediated gene regulation and therapeutic implications

被引：55

作者：

Liu, Yujiao ^{[1
]}

Yang, Dan ^{[1
]}

Liu, Tao ^{[1
]}

Chen, Jianjun ^{[2
]}

Yu, Jianhua ^{[1
,3
,4
]}

Yi, Ping ^{[1
]}

机构：

[1] Chongqing Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 3, Chongqing 401120, Peoples R China

[2] City of Hope, Beckman Res Inst, Dept Syst Biol, Los Angeles, CA 91010 USA

[3] City Hope Natl Med Ctr, Hematol Malignancies Res Inst, Los Angeles, CA 91010 USA

[4] City Hope Natl Med Ctr, Dept Hematol & Hematopoiet Cell Transplantat, Los Angeles, CA 91010 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2023年 / 29卷 / 06期

关键词：

MESSENGER-RNA; HEPATOCELLULAR-CARCINOMA; MOLECULAR-MECHANISMS; PHASE-SEPARATION; SELF-RENEWAL; N-6-METHYLADENOSINE; FTO; METHYLATION; EXPRESSION; TRANSLATION;

D O I：

10.1016/j.molmed.2023.03.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

N6-methyladenosine (m6A) RNA methylation is the most abundant form of mRNA modification in eukaryotes and is at the front line of biological and biomedical re-search. This dynamic and reversible m6A RNA modification determines the fates of modified RNA molecules at the post-transcriptional level, affecting almost all important biological processes. Notably, m6A is also involved in chromatin and transcriptional regulation, while m6A dysregulation is implicated in various dis-eases. Here, we review current knowledge of post-transcriptional and transcrip-tional regulatory mechanisms involving m6A modification. We also discuss their involvement in the occurrence and development of diseases, including cancer, as well as potential theranostic targets, in hope of facilitating the translation of preclinical findings to the clinic.

引用

页码：454 / 467

页数：14