New bi-phosphonate derivative: Synthesis, characterization, antioxidant activity in vitro and via cyclic voltammetry mode and evaluation of its inhibition of SARS-CoV-2 main protease

被引：12

作者：

Houas, Noudjoud ^{[1
,2
]}

Kitouni, Siham ^{[1
,2
]}

Chafai, Nadjib ^{[1
]}

Ghedjati, Samira ^{[3
]}

Djenane, Meriem ^{[1
]}

Tounsi, Assia ^{[4
]}

机构：

[1] Univ Ferhat ABBAS Setif 1, Fac Technol, Complex LEMMC Dept Proc Engn, Lab Electrochem Mol Mat, Setif 19000, Algeria

[2] Univ Ferhat Abbas Setif 1, Fac Sci, Dept Chem, Setif 19000, Algeria

[3] Univ Ferhat Abbas Setif 1, Lab Phytotherapy Appl Chron Dis Fac Nat & Life Sci, Setif 19000, Algeria

[4] Univ Ferhat Abbas Setif 1, Dept Proc Engn, Lab Electrochem & Mat LEM, Setif 19000, Algeria

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2023年 / 1284卷

关键词：

Synthesis; A-aminophosphonates; Antioxidant activity; Cyclic voltammetry; Molecular docking; OXYGEN; DNA;

D O I：

10.1016/j.molstruc.2023.135356

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In this study, we have synthesized a new molecule labeled HBPA. Its molecular structure was determined by spectroscopic methods such as: FT-IR, NMR (H-1, C-13 and P-31); our compound is subjected to two an-tioxidant activities assays: DPPH scavenging and ferric reducing antioxidant power (FRAP); in the results, HBPA was expanded remarkable inhibition when compared especially to standard BHT with values of 14.936 +/- 0.808 and 7.1486 +/- 0.0645 mu g/ml, respectively; in addition to the scavenging test of superoxide anion integrated in electrochemical process, it elucidated a strongly stable interaction towards the radi-cal by evaluating the thermodynamic descriptors (Gibbs free energy Delta G degrees and the binding constant K-b). Besides, the electrochemical behavior of HBPA was distinguished by an irreversible system and for the electrochemical regime adopted at the surface of the electrode; a diffusion governed by a slow charge transfer was deduced. The molecular docking of HBPA was conducted beside Chloroquine and the obtained results were indicated a significant binding with active sites of the SARS-CoV-2 main protease (M-pro). (C) 2023 Elsevier B.V. All rights reserved.

引用

页数：9

共 43 条

[11] Azoimine quinoline derivatives: Synthesis, classical and electrochemical evaluation of antioxidant, anti-inflammatory, antimicrobial activities and the DNA / BSA binding [J].