Research progress on circular RNA vaccines

被引：30
作者：
Bai, Yu [1 ,2 ,3 ]
Liu, Dong [1 ,2 ,3 ]
He, Qian [1 ,2 ,3 ]
Liu, Jianyang [1 ,2 ,3 ]
Mao, Qunying [1 ,2 ,3 ]
Liang, Zhenglun [1 ,2 ,3 ]
机构：
[1] Natl Inst Food & Drug Control, Div Hepatitis & Enterovirus Vaccines, Beijing, Peoples R China
[2] Natl Inst Food & Drug Control, NHC Key Lab Res Qual & Standardizat Biotech Prod, Beijing, Peoples R China
[3] Natl Inst Food & Drug Control, Inst Biol Prod, NMPA Key Lab Qual Res & Evaluat Biol Prod, Beijing, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2023年 / 13卷
关键词：
circular RNA vaccines; research progress; production process; quality control; outlook; TRANSCRIPTS; COVID-19; MECHANISMS; ROLES; GENE; SELF; SRY;
D O I：
10.3389/fimmu.2022.1091797
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Owing to the success of linear mRNA coronavirus disease 2019 (COVID-19) vaccines, biopharmaceutical companies and research teams worldwide have attempted to develop more stable circular RNA (circRNA) vaccines and have achieved some preliminary results. This review aims to summarize key findings and important progress made in circRNA research, the in vivo metabolism and biological functions of circRNAs, and research progress and production process of circRNA vaccines. Further, considerations regarding the quality control of circRNA vaccines are highlighted herein, and the main challenges and problem-solving strategies in circRNA vaccine development and quality control are outlined to provide a reference for circRNA vaccine-related research.
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页数：12
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