Research progress on circular RNA vaccines

被引：41
作者：
Bai, Yu [1 ,2 ,3 ]
Liu, Dong [1 ,2 ,3 ]
He, Qian [1 ,2 ,3 ]
Liu, Jianyang [1 ,2 ,3 ]
Mao, Qunying [1 ,2 ,3 ]
Liang, Zhenglun [1 ,2 ,3 ]
机构：
[1] Natl Inst Food & Drug Control, Div Hepatitis & Enterovirus Vaccines, Beijing, Peoples R China
[2] Natl Inst Food & Drug Control, NHC Key Lab Res Qual & Standardizat Biotech Prod, Beijing, Peoples R China
[3] Natl Inst Food & Drug Control, Inst Biol Prod, NMPA Key Lab Qual Res & Evaluat Biol Prod, Beijing, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2023年 / 13卷
关键词：
circular RNA vaccines; research progress; production process; quality control; outlook; TRANSCRIPTS; COVID-19; MECHANISMS; ROLES; GENE; SELF; SRY;
D O I：
10.3389/fimmu.2022.1091797
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Owing to the success of linear mRNA coronavirus disease 2019 (COVID-19) vaccines, biopharmaceutical companies and research teams worldwide have attempted to develop more stable circular RNA (circRNA) vaccines and have achieved some preliminary results. This review aims to summarize key findings and important progress made in circRNA research, the in vivo metabolism and biological functions of circRNAs, and research progress and production process of circRNA vaccines. Further, considerations regarding the quality control of circRNA vaccines are highlighted herein, and the main challenges and problem-solving strategies in circRNA vaccine development and quality control are outlined to provide a reference for circRNA vaccine-related research.
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页数：12
相关论文
共 121 条
[21]   MISSPLICING YIELDS CIRCULAR RNA MOLECULES [J].
COCQUERELLE, C ;
MASCREZ, B ;
HETUIN, D ;
BAILLEUL, B .
FASEB JOURNAL, 1993, 7 (01) :155-160
[22]   A circRNA from SEPALLATA3 regulates splicing of its cognate mRNA through R-loop formation [J].
Conn, Vanessa M. ;
Hugouvieux, Veronique ;
Nayak, Aditya ;
Conos, Stephanie A. ;
Capovilla, Giovanna ;
Cildir, Gokhan ;
Jourdain, Agnes ;
Tergaonkar, Vinay ;
Schmid, Markus ;
Zubieta, Chloe ;
Conn, Simon J. .
NATURE PLANTS, 2017, 3 (05)
[23]   Assembly and annotation of the mitochondrial minicircle genome of a differentiation-competent strain of Trypanosoma brucei [J].
Cooper, Sinclair ;
Wadsworth, Elizabeth S. ;
Ochsenreiter, Torsten ;
Ivens, Alasdair ;
Savill, Nicholas J. ;
Schnaufer, Achim .
NUCLEIC ACIDS RESEARCH, 2019, 47 (21) :11304-11325
[24]   SARS-CoV-2 Vaccines [J].
Creech, C. Buddy ;
Walker, Shannon C. ;
Samuels, Robert J. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2021, 325 (13) :1318-1320
[25]   The Limitless Future of RNA Therapeutics [J].
Damase, Tulsi Ram ;
Sukhovershin, Roman ;
Boada, Christian ;
Taraballi, Francesca ;
Pettigrew, Roderic I. ;
Cooke, John P. .
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2021, 9
[26]  
Daniel S, 2022, Vaccine Insights, V01, P219, DOI 10.18609/vac.2022.33
[27]   Quality by Design for enabling RNA platform production processes [J].
Daniel, Simon ;
Kis, Zoltan ;
Kontoravdi, Cleo ;
Shah, Nilay .
TRENDS IN BIOTECHNOLOGY, 2022, 40 (10) :1213-1228
[28]   Polypyrimidine tract-binding protein (PTB) and PTB-associated splicing factor in CVB3 infection: an ITAF for an ITAF [J].
Dave, Pratik ;
George, Biju ;
Sharma, Divya Khandige ;
Das, Saumitra .
NUCLEIC ACIDS RESEARCH, 2017, 45 (15) :9068-9084
[29]   Circular RNAs in cell differentiation and development [J].
Di Timoteo, Gaia ;
Rossi, Francesca ;
Bozzoni, Irene .
DEVELOPMENT, 2020, 147 (16)
[30]   RETRACTED: Exosome-mediated transfer of circRNA CircNFIX enhances temozolomide resistance in glioma (Retracted article. See vol. 533, 2022) [J].
Ding, Chenyu ;
Yi, Xuehan ;
Wu, Xiyue ;
Bu, Xingyao ;
Wang, Desheng ;
Wu, Zanyi ;
Zhang, Gaoqi ;
Gu, Jianjun ;
Kang, Dezhi .
CANCER LETTERS, 2020, 479 :1-12
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