System matrix recovery based on deep image prior in magnetic particle imaging

Objective. Magnetic particle imaging (MPI) is an emerging tomography imaging technique with high specificity and temporal-spatial resolution. MPI reconstruction based on the system matrix (SM) is an important research content in MPI. However, SM is usually obtained by measuring the response of an MPI scanner at all positions in the field of view. This process is very time-consuming, and the scanner will overheat in a long period of continuous operation, which is easy to generate thermal noise and affects MPI imaging performance. Approach. In this study, we propose a deep image prior-based method that prominently decreases the time of SM calibration. It is an unsupervised method that utilizes the neural network structure itself to recover a high-resolution SM from a downsampled SM without the need to train the network using a large amount of training data. Main results. Experiments on the Open MPI data show that the time of SM calibration can be greatly reduced with only slight degradation of image quality. Significance. This study provides a novel method for obtaining SM in MPI, which shows the potential to achieve SM recovery at a high downsampling rate. It is expected that this study will increase the practicability of MPI in biomedical applications and promote the development of MPI in the future.