Lessons learned from COVID-19 pandemic: Vaccine platform is a key player

被引:4
作者
Alhashemi, Samira Hossaini [1 ]
Ahmadi, Fatemeh [2 ,4 ]
Dehshahri, Ali [1 ,3 ,4 ]
机构
[1] Shiraz Univ Med Sci, Pharmaceut Sci Res Ctr, Shiraz, Iran
[2] Shiraz Univ Med Sci, Sch Pharm, Dept Pharmaceut, Shiraz, Iran
[3] Shiraz Univ Med Sci, Sch Pharm, Dept Pharmaceut Biotechnol, Shiraz, Iran
[4] Shiraz Univ Med Sci, Sch Pharm, Shiraz, Iran
关键词
Vaccine platform; COVID-19; Vaccine development; Pandemic; LIVE ATTENUATED VACCINES; VIRUS-LIKE PARTICLES; MESSENGER-RNA; CONJUGATED POLYETHYLENIMINE; INTRAMUSCULAR INJECTION; VIRAL VECTORS; DNA VACCINES; NANOPARTICLES; IMMUNITY; CELLS;
D O I
10.1016/j.procbio.2022.12.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The SARS-CoV-2 outbreak and emergence of COVID-19 resulted in the development of different vaccines based on various platforms to combat the disease. While the conventional platforms of inactivated/live attenuated, subunit proteins and virus-like particles (VLPs) have provided efficient and safe vaccines, novel platforms of viral vector-and nucleic acid-based vaccines opened up new horizons for vaccine development. The emergence of COVID-19 pandemic showed that the availability of platforms with high possibility of quick translation from bench to bedside is a prerequisite step in vaccine development in pandemics. Moreover, parallel development of different platforms as well as considering the shipping, storage condition, distribution infrastructure and route of administration are key players for successful and robust response. This review highlights the lessons learned from the current COVID-19 pandemic in terms of vaccine development to provide quick response to future outbreaks of infectious diseases and the importance of vaccine platform in its storage condition and shipping. Finally, the potential application of current COVID-19 vaccine platforms in the treatment of non-infectious diseases has been discussed.
引用
收藏
页码:269 / 279
页数:11
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