Transformation or replacement - Effects of hormone therapy on cardiovascular risk

被引：1

作者：

Kielb, Julia ^{[1
,4
,5
]}

Weber, Jessica ^{[1
,4
,5
]}

Baensch, Leonard ^{[1
,4
]}

Shahjerdi, Khatereh ^{[1
,4
]}

Celik, Aylin ^{[1
,4
]}

Farahat, Nora ^{[1
,4
]}

Riek, Sally ^{[1
,4
]}

Chavez-Talavera, Oscar ^{[1
,4
]}

Grandoch, Maria ^{[2
,3
]}

Polzin, Amin ^{[1
,4
]}

Kelm, Malte ^{[1
,4
]}

Dannenberg, Lisa ^{[1
,4
,5
]}

机构：

[1] Heinrich Heine Univ Dusseldorf, Dept Cardiol Pulmonol & Vasc Med, Med Fac, Dusseldorf, Germany

[2] Heinrich Heine Univ Dusseldorf, Inst Translat Pharmacol, Med Fac, Dusseldorf, Germany

[3] Heinrich Heine Univ Dusseldorf, Univ Hosp Dusseldorf, Dusseldorf, Germany

[4] Cardiovasc Res Inst Dusseldorf CARID, Dusseldorf, Germany

[5] Univ Hosp Dusseldorf, Dept Cardiol Pneumol & Vasc Med, Moorenstr 5, D-40225 Dusseldorf, Germany

来源：

PHARMACOLOGY & THERAPEUTICS | 2024年 / 254卷

关键词：

Hormone therapy; Cardiovascular risk; Menopause; Transgender; VASCULAR ENDOTHELIAL-CELLS; ESTROGEN PLUS PROGESTIN; TESTOSTERONE THERAPY; MYOCARDIAL-INFARCTION; MEDROXYPROGESTERONE ACETATE; PLATELET-AGGREGATION; POSTMENOPAUSAL WOMEN; TRANSGENDER MEN; IN-VITRO; RECEPTOR;

D O I：

10.1016/j.pharmthera.2024.108592

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hormone therapy (HT) is important and frequently used both regarding replacement therapy (HRT) and gender affirming therapy (GAHT). While HRT has been effective in addressing symptoms related to hormone shortage, several side effects have been described. In this context, there are some studies that show increased cardiovascular risk. However, there are also studies reporting protective aspects of HT. Nevertheless, the exact impact of HT on cardiovascular risk and the underlying mechanisms remain poorly understood. This article explores the relationship between diverse types of HT and cardiovascular risk, focusing on mechanistic insights of the underlying hormones on platelet and leukocyte function as well as on effects on endothelial and adipose tissue cells. (c) 2024 Elsevier Inc. All rights reserved.

引用

页数：9

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