Wharton's jelly and osteoarthritis of the knee

被引:10
作者
Aratikatla, Adarsh [1 ]
Maffulli, Nicola [2 ,3 ,4 ,5 ,11 ]
Gupta, Manu [6 ]
Potti, Ishana A. [7 ]
Potty, Anish G. [7 ]
Gupta, Ashim [7 ,8 ,9 ,10 ]
机构
[1] Royal Coll Surgeons Ireland, Dublin D02 YN77, Ireland
[2] Univ Salerno, Dept Musculoskeletal Disorders, I-84084 Fisciano, Italy
[3] Sapienza Univ Rome, Osped St Andrea, Dept Trauma & Orthopaed, Rome, Italy
[4] Queen Mary Univ London, Barts & London Sch Med & Dent, Ctr Sports & Exercise Med, London E1 4DG, England
[5] Keele Univ, Sch Pharm & Bioengn, Sch Med, Stoke On Trent ST5 5BG, England
[6] Polar Aesthet Dent & Cosmet Ctr, Noida 201301, Uttar Pradesh, India
[7] South Texas Orthopaed Res Inst STORI Inc, Laredo, TX 78045 USA
[8] Future Biol, Lawrenceville, GA 30043 USA
[9] BioIntegrate, Lawrenceville, GA 30043 USA
[10] Regenerat Orthopaed, Noida 201301, India
[11] Queen Mary Univ London, Mile End Hosp, 275 Bancroft Rd, London E1 4DG, England
关键词
umbilical cord; Wharton's jelly; regenerative medicine; perinatal tissue; osteoarthritis; knee osteoarthritis; MESENCHYMAL STEM-CELLS; UMBILICAL-CORD TISSUE; SCAFFOLD; REGENERATION; PROGRESSION;
D O I
10.1093/bmb/ldad030
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction The existing treatment modalities for knee osteoarthritis (OA) do not actually address the pathology. Biological therapies, including those using material derived from perinatal tissues, represent a ground-breaking approach to alleviating the symptoms of OA of the knee.Source of data Current scientific literature published in PubMed (MEDLINE), Embase and Scopus databases. Trials registered in various clinical trial databases.Areas of agreement Perinatal tissues including Wharton's jelly (WJ) and associated mesenchymal stem cells (MSCs) can be used for the management of knee OA.Areas of controversy The efficacy of WJ and associated MSCs in the management of knee OA is still controversial.Growing points The use of WJ and associated MSCs in the management of knee OA is safe and appears to be effective.Areas timely for developing research The present published evidence suggests that WJ tissue and associated MSCs offer an encouraging alternative for the management of knee OA. The published in vitro, preclinical and clinical investigations demonstrate the therapeutic potential of WJ and promote further research in this field to provide symptomatic relief to patients suffering from OA, aiming also to regenerate the osteoarthritic hyaline cartilage, with disease-modifying effects. Future adequately powered randomized controlled trials should be undertaken to establish whether WJ is helpful in the management of OA of the knee.
引用
收藏
页码:13 / 31
页数:19
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