Prospective, multicenter validation of the deep learning-based cardiac arrest risk management system for predicting in-hospital cardiac arrest or unplanned intensive care unit transfer in patients admitted to general wards

BackgroundRetrospective studies have demonstrated that the deep learning-based cardiac arrest risk management system (DeepCARS & TRADE;) is superior to the conventional methods in predicting in-hospital cardiac arrest (IHCA). This prospective study aimed to investigate the predictive accuracy of the DeepCARS & TRADE; for IHCA or unplanned intensive care unit transfer (UIT) among general ward patients, compared with that of conventional methods in real-world practice.MethodsThis prospective, multicenter cohort study was conducted at four teaching hospitals in South Korea. All adult patients admitted to general wards during the 3-month study period were included. The primary outcome was predictive accuracy for the occurrence of IHCA or UIT within 24 h of the alarm being triggered. Area under the receiver operating characteristic curve (AUROC) values were used to compare the DeepCARS & TRADE; with the modified early warning score (MEWS), national early warning Score (NEWS), and single-parameter track-and-trigger systems.ResultsAmong 55,083 patients, the incidence rates of IHCA and UIT were 0.90 and 6.44 per 1,000 admissions, respectively. In terms of the composite outcome, the AUROC for the DeepCARS & TRADE; was superior to those for the MEWS and NEWS (0.869 vs. 0.756/0.767). At the same sensitivity level of the cutoff values, the mean alarm counts per day per 1,000 beds were significantly reduced for the DeepCARS & TRADE;, and the rate of appropriate alarms was higher when using the DeepCARS & TRADE; than when using conventional systems.ConclusionThe DeepCARS & TRADE; predicts IHCA and UIT more accurately and efficiently than conventional methods. Thus, the DeepCARS & TRADE; may be an effective screening tool for detecting clinical deterioration in real-world clinical practice.Trial registration This study was registered at ClinicalTrials.gov (NCT04951973) on June 30, 2021.ConclusionThe DeepCARS & TRADE; predicts IHCA and UIT more accurately and efficiently than conventional methods. Thus, the DeepCARS & TRADE; may be an effective screening tool for detecting clinical deterioration in real-world clinical practice.Trial registration This study was registered at ClinicalTrials.gov (NCT04951973) on June 30, 2021.