Substantial changes in inflammatory and cardiovascular biomarkers in patients with autonomous cortisol secretion

被引：3
作者：
Ueland, Grethe A. [1 ]
Methlie, Paal [1 ,2 ]
Heie, Anette [3 ]
Stokland, Ann-Elin Meling [2 ,4 ]
Dahle, Anne Lise [5 ]
Saevik, Ase B. [2 ]
Lovas, Kristian [1 ]
Husebye, Eystein S. [1 ,2 ]
机构：
[1] Haukeland Hosp, Dept Med, Jonas Lies Vei 65, N-5021 Bergen, Norway
[2] Univ Bergen, Dept Clin Sci, Haukelandsveien 9, N-5009 Bergen, Norway
[3] Haukeland Hosp, Dept Surg, Jonas Liesvei 65, N-5021 Bergen, Norway
[4] Stavanger Univ Hosp, Dept Med, Gerd Ragna Bloch Thorsens Gate 8, N-4019 Stavanger, Norway
[5] Haugesund Hosp, Dept Med, Karmsundgata 120, N-5528 Haugesund, Norway
来源：
EUROPEAN JOURNAL OF ENDOCRINOLOGY | 2023年 / 189卷 / 01期
关键词：
autonomous cortisol secretion; Cushing syndrome; proteomics; inflammation; cardiovascular biomarkers; SUBCLINICAL CUSHINGS-SYNDROME; INAPPARENT ADRENAL MASS; SERUM-LEVELS; INCIDENTALOMAS; DISEASE; MORTALITY; MANAGEMENT; MARKERS; HYPERCORTISOLISM; PREVALENCE;
D O I：
10.1093/ejendo/lvad076
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective To map inflammatory biomarkers in patients with autonomous cortisol secretion (ACS) and overt Cushing syndrome (CS). Method Observational study including serum from prospectively included patients with ACS (n = 63), adrenal CS (n = 2), pituitary CS (n = 8), and healthy subjects (n = 120). Serum samples were analysed for 92 inflammatory biomarkers using proximity extension assay (OLINK). Results Combined, the ACS and CS patients displayed significant differences in levels of 49/92 inflammatory biomarkers (46 increased/3 decreased) compared with healthy controls. No differences in biomarker levels were found between ACS and overt CS, and none of the biomarkers correlated with the degree of hypercortisolism. Postoperative samples were available for 17 patients, median 24 months (range 6-40) after surgery and biochemical curation. There was no significant normalization of the biomarkers postoperatively. Conclusion There was a systemic rise in inflammatory biomarkers in patients with ACS and CS, not correlated to the degree of hypercortisolism. These biomarkers were not normalized following biochemical cure.
引用
收藏
页码：78 / 86
页数：9
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