Outcomes of Patients with Monoclonal Gammopathy of Undetermined Significance with and without Atrial Fibrillation: A Retrospective Cohort Analysis of the Nationwide Inpatient Sample Database

被引:1
作者
Hamadi, Rachelle [1 ]
Alameddine, Zakaria [1 ]
Asmar, Samer [1 ]
Sakr, Fouad [1 ]
Aridi, Hussam [1 ]
Dimachkie, Reem [1 ]
Skouri, Hadi [2 ]
机构
[1] Staten Isl Univ Hosp, Internal Med Dept, 475 Seaview Ave, Staten Isl, NY 10305 USA
[2] Sheikh Shakhbout Med City Mayo Clin, Cardiol Dept, POB 11001, Abu Dhabi, U Arab Emirates
关键词
MGUS; AFIB; mortality; AKI; pericarditis;
D O I
10.3390/jcm12134436
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Monoclonal gammopathy of undetermined significance (MGUS) is a non-malignant precursor of multiple myeloma (MM). MGUS has been suggested to be associated with a higher risk of cardiovascular diseases, including AFIB, but it is still unclear whether this association is real. Studies are lacking on the impact of atrial fibrillation on health outcomes in this population. The association of AFIB in this population is lagging and merits further investigation. Methods: The study conducted a retrospective analysis of the Nationwide Inpatient Sample (NIS) for 2018, including adult patients with primary diagnoses of MGUS and AFIB. Patients were divided into two groups based on AFIB presence. Outcomes assessed included complications, length of stay, mortality, hospital charges, and discharge disposition. Results: The study included 9007 patients with MGUS of whom 2404 had AFIB. Patients with both MGUS and AFIB had higher rates of acute kidney injury [AKI] (31.5% vs. 27.5%; p = 0.002) and pericarditis (2% vs. 1.2%; p = 0.029). They also had longer hospital stays (5 vs. 4 days; p < 0.001) and higher hospitalization costs ($43,729 vs. $41,169; p < 0.001). Conclusions: The study showed that the prevalence of AFIB in MGUS patients is high. Patients with AFIB had increased rates of complications (AKI and pericarditis) and higher mortality compared to patients without AFIB. Further studies screening for AFIB in this patient population are warranted.
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页数:9
相关论文
共 12 条
[1]   Atrial fibrillation in acute pericarditis: an overblown association [J].
Chhabra, Lovely ;
Bhattad, Venugopal Brijmohan ;
Sareen, Pooja ;
Khalid, Nauman ;
Spodick, David H. .
HEART, 2015, 101 (18) :1518-1518
[2]   How I manage monoclonal gammopathy of undetermined significance [J].
Go, Ronald S. ;
Rajkumar, S. Vincent .
BLOOD, 2018, 131 (02) :163-173
[3]   Impact of Atrial Fibrillation on Inpatient Outcomes Among Hospitalized Patients With Multiple Myeloma [J].
Jackson, Inimfon ;
Etuk, Aniekeme S. ;
Jackson, Nsikak .
CUREUS JOURNAL OF MEDICAL SCIENCE, 2022, 14 (05)
[4]   Cardiovascular Associations With Monoclonal Gammopathy of Undetermined Significance Real or Coincidental? [J].
Kapoor, Prashant ;
Rajkumar, S. Vincent .
JACC: CARDIOONCOLOGY, 2022, 4 (03) :323-325
[5]   Deep vein thrombosis after monoclonal gammopathy of undetermined significance and multiple myeloma [J].
Kristinsson, Sigurdur Y. ;
Fears, Thomas R. ;
Gridley, Gloria ;
Turesson, Ingemar ;
Mellqvist, Ulf-Henrik ;
Bjoerkholm, Magnus ;
Landgren, Ola .
BLOOD, 2008, 112 (09) :3582-3586
[6]   Patterns of survival and causes of death following a diagnosis of monoclonal gammopathy of undetermined significance: a population-based study [J].
Kristinsson, Sigurdur Y. ;
Bjorkholm, Magnus ;
Andersson, Therese M-L ;
Eloranta, Sandra ;
Dickman, Paul W. ;
Goldin, Lynn R. ;
Blimark, Cecilie ;
Mellqvist, Ulf-Henrik ;
Wahlin, Anders ;
Turesson, Ingemar ;
Landgren, Ola .
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2009, 94 (12) :1714-1720
[7]   Acute Kidney Injury in Monoclonal Gammopathies [J].
Mene, Paolo ;
Moioli, Alessandra ;
Stoppacciaro, Antonella ;
Lai, Silvia ;
Festuccia, Francescaromana .
JOURNAL OF CLINICAL MEDICINE, 2021, 10 (17)
[8]  
Nesheiwat Z, 2023, StatPearls
[9]   Monoclonal gammopathies of clinical significance (MGCS): In pursuit of optimal treatment [J].
Oganesyan, Artem ;
Gregory, Andrew ;
Malard, Florent ;
Ghahramanyan, Nerses ;
Mohty, Mohamad ;
Kazandjian, Dickran ;
Mekinian, Arsene ;
Hakobyan, Yervand .
FRONTIERS IN IMMUNOLOGY, 2022, 13
[10]   Cardiovascular Morbidity in Monoclonal Gammopathy of Undetermined Significance A Danish Nationwide Study [J].
Schwartz, Brian ;
Schou, Morten ;
Ruberg, Frederick L. ;
Rucker, Dane ;
Choi, Jihoon ;
Siddiqi, Omar ;
Monahan, Kevin ;
Kober, Lars ;
Gislason, Gunnar ;
Torp-Pedersen, Christian ;
Andersson, Charlotte .
JACC: CARDIOONCOLOGY, 2022, 4 (03) :313-322