Hypoxia-stabilized RIPK1 promotes cell death

被引：1

作者：

Ruan, Wei ^{[1
]}

Eltzschig, Holger K. ^{[1
,2
]}

Yuan, Xiaoyi ^{[1
]}

机构：

[1] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Anesthesiol Crit Care & Pain Med, Houston, TX 77030 USA

[2] Outcomes Res Consortium, Cleveland, OH USA

来源：

NATURE CELL BIOLOGY | 2023年 / 25卷 / 07期

关键词：

ISCHEMIA; HIF;

D O I：

10.1038/s41556-023-01176-y

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The PHD–pVHL pathway is essential for oxygen-dependent prolyl hydroxylation of HIFA. A recent study identifies RIPK1 as a hydroxylation target in this pathway during hypoxia-induced cell death and presents a 2.8 Å resolution crystal structure of the pVHL–elongin B/C complex bound to hydroxylated RIPK1.

引用

页码：921 / 922

页数：2

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