Hypoxia-stabilized RIPK1 promotes cell death

被引：1
|
作者：
Ruan, Wei [1 ]
Eltzschig, Holger K. [1 ,2 ]
Yuan, Xiaoyi [1 ]
机构：
[1] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Anesthesiol Crit Care & Pain Med, Houston, TX 77030 USA
[2] Outcomes Res Consortium, Cleveland, OH USA
来源：
NATURE CELL BIOLOGY | 2023年 / 25卷 / 07期
关键词：
ISCHEMIA; HIF;
D O I：
10.1038/s41556-023-01176-y
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The PHD–pVHL pathway is essential for oxygen-dependent prolyl hydroxylation of HIFA. A recent study identifies RIPK1 as a hydroxylation target in this pathway during hypoxia-induced cell death and presents a 2.8 Å resolution crystal structure of the pVHL–elongin B/C complex bound to hydroxylated RIPK1.
引用
收藏
页码：921 / 922
页数：2
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