The Pathogenesis of Diabetes

被引：34
作者：
Guo, Huiqin [1 ]
Wu, Haili [2 ]
Li, Zhuoyu [1 ]
机构：
[1] Shanxi Univ, Inst Biotechnol, Key Lab Chem Biol & Mol Engn, Minist Educ, Taiyuan, Peoples R China
[2] Shanxi Univ, Coll Life Sci, Taiyuan 030006, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 08期
基金：
中国国家自然科学基金;
关键词：
diabetes; signal pathway; insulin resistance; hyperglycemia; long-chain non-coding RNA (lncRNAs); PANCREATIC BETA-CELL; INHIBITS HEPATIC GLUCONEOGENESIS; LONG NONCODING RNA; INCREASES GLYCOGEN-SYNTHESIS; INSULIN SIGNALING PATHWAY; GENE-EXPRESSION; GLUCOSE-HOMEOSTASIS; SKELETAL-MUSCLE; DOWN-REGULATION; CARDIOMYOCYTE APOPTOSIS;
D O I：
10.3390/ijms24086978
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Diabetes is the most common metabolic disorder, with an extremely serious effect on health systems worldwide. It has become a severe, chronic, non-communicable disease after cardio-cerebrovascular diseases. Currently, 90% of diabetic patients suffer from type 2 diabetes. Hyperglycemia is the main hallmark of diabetes. The function of pancreatic cells gradually declines before the onset of clinical hyperglycemia. Understanding the molecular processes involved in the development of diabetes can provide clinical care with much-needed updates. This review provides the current global state of diabetes, the mechanisms involved in glucose homeostasis and diabetic insulin resistance, and the long-chain non-coding RNA (lncRNA) associated with diabetes.
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页数：23
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