Impact of two-field or three-field lymphadenectomy on overall survival in middle and lower thoracic esophageal squamous cell carcinoma: A single-center retrospective analysis

被引:9
作者
Li, Kexun [1 ]
Du, Kunyi [1 ]
Liu, Kun [1 ]
Nie, Xin [1 ]
Li, Changding [1 ]
He, Wenwu [1 ]
Li, Kunzhi [1 ]
Wang, Chenghao [1 ]
Li, Zhiyu [1 ]
Zheng, Kai [1 ]
Mao, Tianqin [1 ]
Jiang, Longlin [1 ]
Li, Haojun [1 ]
Miao, Yan [1 ]
Xie, Qin [1 ]
Fang, Qiang [1 ]
Han, Yongtao [1 ]
Leng, Xuefeng [1 ,2 ]
Peng, Lin [1 ,2 ]
机构
[1] Univ Elect Sci & Technol China, Sichuan Canc Hosp & Inst, Sichuan Canc Res Ctr Canc, Affiliated Canc Hosp,Div Thorac Surg,Sichuan Canc, Chengdu 610041, Sichuan, Peoples R China
[2] Univ Elect Sci & Technol China, Sichuan Canc Hosp & Inst, Sichuan Canc Res Ctr Canc, Affiliated Canc Hosp,Div Thorac Surg,Sichuan Canc, 55 South Renmin Rd, Chengdu 610041, Sichuan, Peoples R China
关键词
esophageal cancer; squamous cell carcinoma; lymph node; two-field lymphadenectomy; three-field lymphadenectomy; LYMPH-NODE DISSECTION; CANCER;
D O I
10.3892/ol.2023.13774
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Squamous cell carcinoma is the main subtype of esophageal cancer in East Asia. The effect of the number of lymph nodes (LNs) removed to treat middle and lower thoracic esophageal squamous cell carcinoma (ESCC) in China remains controversial. Therefore, the present study aimed to investigate the impact of the number of LNs removed during lymphadenectomy on the survival of patients with middle and lower thoracic ESCC. Data were obtained from the Sichuan Cancer Hospital and Institute Esophageal Cancer Case Management Database from January 2010 to April 2020. Either three-field systematic lymphadenectomy (3F group) or two-field systematic lymphadenectomy (2F group) was performed for ESCC cases with or without suspicious tumor-positive cervical LNs, respectively. Subgroups were designed for further analysis based on the quartile number of resected LNs. After 50.7 months of median follow-up, 1,659 patients who underwent esophagectomy were enrolled. The median overall survival (OS) of the 2F and 3F groups was 50.0 months and 58.5 months, respectively. The OS rates at 1, 3 and 5 years were 86, 57 and 47%, respectively, in the 2F group, and 83, 52 and 47%, respectively, in the 3F group (P=0.732). The average OS of the 3F B and D groups was 57.7 months and 30.2 months, respectively (P=0.006). In the 2F group, the OS between subgroups was not significantly different. In conclusion, resection of >15 LNs during two-field dissection in patients with ESCC undergoing esophagectomy did not affect their survival outcomes. In three-field lymphadenectomy, the extent of LNs removed could lead to different survival outcomes.
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页数:10
相关论文
共 29 条
[1]   RADICAL LYMPH-NODE DISSECTION FOR CANCER OF THE THORACIC ESOPHAGUS [J].
AKIYAMA, H ;
TSURUMARU, M ;
UDAGAWA, H ;
KAJIYAMA, Y .
ANNALS OF SURGERY, 1994, 220 (03) :364-373
[2]   Three-field lymph node dissection for squamous cell and adenocarcinoma of the esophagus [J].
Altorki, N ;
Kent, M ;
Ferrara, C ;
Port, J .
ANNALS OF SURGERY, 2002, 236 (02) :177-183
[3]  
Amin MB., 2017, AJCC CANC STAGING MA, V8th, DOI [10.1007/978-3-319-40618-3, DOI 10.1007/978-3-319-40618-3]
[4]   Lymph Node Dissection after Chemoradiation in Esophageal Cancer: A Subgroup Analysis of Patients With and Without Pathological Response [J].
Chao, Yin-Kai ;
Liu, Hui-Ping ;
Hsieh, Ming-Ju ;
Wu, Yi-Cheng ;
Liu, Yun-Hen ;
Yeh, Chi-Hsiao ;
Chang, Hsien-Kun ;
Tseng, Chen-Kan .
ANNALS OF SURGICAL ONCOLOGY, 2012, 19 (11) :3500-3505
[5]   Comparison of endoscopic ultrasonography (EUS), positron emission tomography (PET), and computed tomography (CT) in the preoperative locoregional staging of resectable esophageal cancer [J].
Choi, Jeongmin ;
Kim, Sang Gyun ;
Kim, Joo Sung ;
Jung, Hyun Chae ;
Song, In Sung .
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 2010, 24 (06) :1380-1386
[6]  
CSCO, 2022, Guidelines of Chinese Society of Clinical Oncology (csco) lymphoma
[7]   Impact of Lymph Node Dissection on Survival After Neoadjuvant Chemoradiotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma From the Results of NEOCRTEC5010, a Randomized Multicenter Study [J].
Guo, Xufeng ;
Wang, Zhexin ;
Yang, Hong ;
Mao, Teng ;
Chen, Yuping ;
Zhu, Chengchu ;
Yu, Zhentao ;
Han, Yongtao ;
Mao, Weimin ;
Xiang, Jiaqing ;
Chen, Zhijian ;
Liu, Hui ;
Yang, Haihua ;
Wang, Jiaming ;
Pang, Qingsong ;
Zheng, Xiao ;
Yang, Huanjun ;
Li, Tao ;
Zhang, Xu ;
Li, Qun ;
Wang, Geng ;
Lin, Ting ;
Liu, Mengzhong ;
Fu, Jianhua ;
Fang, Wentao .
ANNALS OF SURGERY, 2023, 277 (02) :259-266
[8]   How Does the Number of Resected Lymph Nodes Influence TNM Staging and Prognosis for Esophageal Carcinoma? [J].
Hu, Yang ;
Hu, Chunyan ;
Zhang, Helin ;
Ping, Yumin ;
Chen, Long-Qi .
ANNALS OF SURGICAL ONCOLOGY, 2010, 17 (03) :784-790
[9]   Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer [J].
Kelly, Ronan J. ;
Ajani, Jaffer A. ;
Kuzdzal, Jaroslaw ;
Zander, Thomas ;
Van Cutsem, Eric ;
Piessen, Guillaume ;
Mendez, Guillermo ;
Feliciano, Josephine ;
Motoyama, Satoru ;
Lievre, Astrid ;
Uronis, Hope ;
Elimova, Elena ;
Grootscholten, Cecile ;
Geboes, Karen ;
Zafar, Syed ;
Snow, Stephanie ;
Ko, Andrew H. ;
Feeney, Kynan ;
Schenker, Michael ;
Kocon, Piotr ;
Zhang, Jenny ;
Zhu, Lili ;
Lei, Ming ;
Singh, Prianka ;
Kondo, Kaoru ;
Cleary, James M. ;
Moehler, Markus .
NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (13) :1191-1203
[10]   Strong Impact of Micrometastatic Tumor Cell Load in Patients with Esophageal Carcinoma [J].
Koenig, Alexandra M. ;
Prenzel, Klaus L. ;
Bogoevski, Dean ;
Yekebas, Emre F. ;
Bubenheim, Michael ;
Faithova, Lucia ;
Vashist, Yogesh K. ;
Gawad, Karim A. ;
Baldus, Stephan E. ;
Pantel, Klaus ;
Schneider, Paul M. ;
Hoelscher, Arnulf H. ;
Izbicki, Jakob R. .
ANNALS OF SURGICAL ONCOLOGY, 2009, 16 (02) :454-462