The Role of Rosavin in the Pathophysiology of Bone Metabolism

被引:5
作者
Wojdasiewicz, Piotr [1 ]
Turczyn, Pawel [2 ]
Lach-Gruba, Anna [3 ]
Poniatowski, Lukasz A. [4 ]
Purrahman, Daryush [5 ]
Mahmoudian-Sani, Mohammad-Reza [5 ]
Szukiewicz, Dariusz [1 ]
机构
[1] Med Univ Warsaw, Fac Hlth Sci, Dept Biophys Physiol & Pathophysiol, Chałubińskiego 5, PL-02004 Warsaw, Poland
[2] Eleonora Reicher Natl Inst Geriatr Rheumatol & Reh, Dept Early Arthrit, Spartańska 1, PL-02637 Warsaw, Poland
[3] St Annas Trauma Surg Hosp, Mazovian Rehabil Ctr STOCER, Dept Rehabil, Barska 16-20, PL-02315 Warsaw, Poland
[4] Dietrich Bonhoeffer Klinikum, Dept Neurosurg, Salvador Allende Str 30, D-17036 Neubrandenburg, Germany
[5] Ahvaz Jundishapur Univ Med Sci, Hlth Res Inst, Thalassemia & Hemoglobinopathy Res Ctr, Ahvaz, Iran
关键词
rosavin; adaptogens; bone metabolism; osteoblasts; osteoporosis; Rhodiola rosea; bone loss; osteoclastogenesis; osteogenesis; OSTEOPOROSIS-RELATED FRACTURES; HISTONE DEACETYLASES; COSTS; DIFFERENTIATION; OSTEOARTHRITIS;
D O I
10.3390/ijms25042117
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Rosavin, a phenylpropanoid in Rhodiola rosea's rhizome, and an adaptogen, is known for enhancing the body's response to environmental stress. It significantly affects cellular metabolism in health and many diseases, particularly influencing bone tissue metabolism. In vitro, rosavin inhibits osteoclastogenesis, disrupts F-actin ring formation, and reduces the expression of osteoclastogenesis-related genes such as cathepsin K, calcitonin receptor (CTR), tumor necrosis factor receptor-associated factor 6 (TRAF6), tartrate-resistant acid phosphatase (TRAP), and matrix metallopeptidase 9 (MMP-9). It also impedes the nuclear factor of activated T-cell cytoplasmic 1 (NFATc1), c-Fos, the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B), and mitogen-activated protein kinase (MAPK) signaling pathways and blocks phosphorylation processes crucial for bone resorption. Moreover, rosavin promotes osteogenesis and osteoblast differentiation and increases mouse runt-related transcription factor 2 (Runx2) and osteocalcin (OCN) expression. In vivo studies show its effectiveness in enhancing bone mineral density (BMD) in postmenopausal osteoporosis (PMOP) mice, restraining osteoclast maturation, and increasing the active osteoblast percentage in bone tissue. It modulates mRNA expressions by increasing eukaryotic translation elongation factor 2 (EEF2) and decreasing histone deacetylase 1 (HDAC1), thereby activating osteoprotective epigenetic mechanisms, and alters many serum markers, including decreasing cross-linked C-telopeptide of type I collagen (CTX-1), tartrate-resistant acid phosphatase 5b (TRACP5b), receptor activator for nuclear factor kappa B ligand (RANKL), macrophage-colony-stimulating factor (M-CSF), and TRAP, while increasing alkaline phosphatase (ALP) and OCN. Additionally, when combined with zinc and probiotics, it reduces pro-osteoporotic matrix metallopeptidase 3 (MMP-3), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-alpha), and enhances anti-osteoporotic interleukin 10 (IL-10) and tissue inhibitor of metalloproteinase 3 (TIMP3) expressions. This paper aims to systematically review rosavin's impact on bone tissue metabolism, exploring its potential in osteoporosis prevention and treatment, and suggesting future research directions.
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页数:13
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