Knockdown of FOXRED2 restrains proliferation, invasion and migration of human melanoma cells

被引：0
|
作者：
Li, Mujin [1 ,2 ]
Qin, Si [1 ]
Xu, Zhijun [2 ]
Feng, Yingjun [1 ]
Li, Sihui [1 ]
Li, Xianwen [1 ]
Lu, Zhenyu [3 ]
Huang, Shuting [1 ]
Shi, Siman [1 ]
Duan, Yixue [1 ]
Wen, Ju [1 ,4 ]
机构：
[1] Guangdong Second Prov Gen Hosp, Dept Dermatol, Guangzhou 510317, Peoples R China
[2] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Shenshan Med Ctr, Shanwei 516621, Peoples R China
[3] Guangzhou Med Univ, Dept Dermatol, Affiliated Hosp 5, Guangzhou 510799, Peoples R China
[4] Guangdong Second Prov Gen Hosp, 466 Middle Xingang Rd, Guangzhou 510317, Peoples R China
来源：
HELIYON | 2023年 / 9卷 / 12期
关键词：
FOXRED2; protein; Cutaneous malignant melanoma; Bioinformatics; Human melanoma cell lines; Tumor biology; CENTRAL DOGMA; WEB SERVER; CANCER; FLAVOPROTEIN;
D O I：
10.1016/j.heliyon.2023.e22588
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Objectives: This experiment investigated the role of the FAD-dependent oxidoreductase domaincontaining 2 (FOXRED2) in the development of cutaneous malignant melanoma. Methods: We explored the expression and prognostic effects of FOXRED2 in cutaneous malignant melanoma by performing bioinformatics analyses and immunohistochemical staining experiments and verified the biological influence of FOXRED2 on human melanoma cells using in vitro experiments. Results: FOXRED2 expression was significantly higher in cutaneous malignant melanoma compared to normal skin and nevus tissues and closely associated with prognosis. The expression levels of FOXRED2 mRNA and protein were significantly upregulated in human melanoma cell lines, and knocking down FOXRED2 expression inhibits proliferation, invasion, and migration, promotes apoptosis, and alters tumor cell biology in A2058 and A375 cells. Conclusion: FOXRED2 may play a crucial role in the development and progression of cutaneous malignant melanoma.
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页数：12
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