Selective Cross-Dehydrogenative Coupling of Various Acyclic Enamides with Heteroarenes via Rh(III)-Catalyzed C-H Activation

被引：10

作者：

Li, Xiaolan ^{[1
,2
]}

Luo, Haiqing ^{[2
]}

Song, Ruixin ^{[2
]}

Zhang, Yuting ^{[2
]}

Gong, Xian ^{[2
]}

Cai, Hu ^{[1
]}

Luo, Xuzhong ^{[1
,2
]}

机构：

[1] Nanchang Univ, Coll Chem, Nanchang 330031, Jiangxi, Peoples R China

[2] Gannan Normal Univ, Dept Chem & Chem Engn, Ganzhou 341000, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 28期

基金：

中国国家自然科学基金;

关键词：

CATALYZED DIRECT ARYLATION; CYCLIC ENAMIDES; ACCESS; TRIFLUOROMETHYLATION; PHOSPHORYLATION; DERIVATIVES; OLEFINATION; ACYLATION; ALDEHYDES; BONDS;

D O I：

10.1021/acs.orglett.3c01786

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The developed methodology describes an efficient Rh(III)-catalyzedoxidative C-H/C-H cross-coupling between acyclic enamidesand heteroarenes. This cross dehydrogenative coupling (CDC) reactionoffers advantages, including excellent regioselectivity and stereoselectivity,good functional group compatibility, and a broad substrate scope.Mechanistically, Rh(III)-catalyzed & beta;-C(sp(2))-H activation of acyclic enamides is proposed to be the criticalstep.

引用

页码：5262 / 5267

页数：6

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