Diastereoselective Synthesis of Trans-1H-Chromeno[2,3-d]Pyrimidine-2,4,6(3H)-Trione Derivatives by KF/Stilbite Zeolite NPs as a Novel Heterogeneous Nanocatalyst and Evaluation of Their Antimicrobial and Antioxidant Activity

A green protocol for diastereoselective synthesis of trans-trans-1H-Chromeno[2,3-d]pyrimidine-2,4,6(3H)-trione was applied by tandem aldol-Michael reactions between 1,3-dimethylbarbituric acid, aldehydes, and dimedone at room temperature on the water as well as the present of KF/Stilbite nanoparticles. Also, the catalytic activity of the nanocatalyst (NC) was evaluated in the reduction of organic pollutants such as 4-nitrophenol (4-NP) in water at mild conditions. The results indicated that the NCs have very high and effective catalytic activity for organic pollutants within a few seconds. Antioxidant abilities of synthesized compounds were revealed using radical trapping of diphenyl-picrylhydrazine (DPPH) and ferric reduction power experiments. The compounds 4a-d had excellent DPPH center dot radical scavenging. Also, the antimicrobial activity of some synthesized compounds was proved by employing the disk diffusion test on Gram-positive and Gram-negative bacteria.